3例子宮體原發(fā)性非霍奇金淋巴瘤的臨床病理觀察
本文選題:淋巴瘤 + 非霍奇金 ; 參考:《重慶醫(yī)學》2017年14期
【摘要】:目的探討3例原發(fā)于子宮體非霍奇金淋巴瘤(NHL)臨床病理特點。方法收集3例原發(fā)于子宮體NHL的臨床病理資料,采用免疫組織化學方法標記腫瘤細胞,按最新WHO淋巴造血組織腫瘤分類進行組織學分型,并與子宮其他疾病進行鑒別診斷。結果 3個病例均以異常陰道排液或出血為首發(fā)癥狀就診,臨床及病理都誤診為子宮常見疾病。子宮標本組織病理顯示:病例1腫瘤細胞表達CD3、CD56及TiA-1等抗原,且EBV病毒表達陽性,支持NK/T細胞淋巴瘤的診斷。病例2和病例3腫瘤細胞表達B細胞特異抗原標記CD20等,腫瘤細胞體積為淋巴細胞的3倍,增殖指數(shù)高,支持彌漫性大B細胞淋巴瘤的診斷。結論 3例病例鏡下腫瘤細胞似淋巴細胞樣,彌漫浸潤子宮內膜及肌壁間,與子宮內膜間質肉瘤等難以鑒別,需借助免疫組織化學方法進行確診及鑒別診斷。
[Abstract]:Objective to investigate the clinicopathological features of 3 cases of primary non-Hodgkin's lymphoma (NHL) in the uterus. Methods the clinicopathological data of 3 cases of primary NHL in uterine body were collected. The tumor cells were labeled with immunohistochemical method. Histological classification was performed according to the latest WHO classification of lymphoid hematopoietic tumors, and differential diagnosis was made between NHL and other uterine diseases. Results the first symptoms of the three cases were abnormal vaginal effusion or hemorrhage, and the clinical and pathological diagnosis were misdiagnosed as common uterine diseases. Histopathological findings of uterine specimens showed that tumor cells in case 1 expressed CD3 + CD56 and TiA-1 antigens, and EBV virus was positive, which supported the diagnosis of NKR / T cell lymphoma. Cases 2 and 3 showed that tumor cells expressed B cell specific antigen labeled CD20 and the tumor cells were 3 times larger than lymphocytes and had high proliferative index which supported the diagnosis of diffuse large B cell lymphoma. Conclusion the tumor cells in 3 cases were lymphocyte-like and diffusely infiltrated the endometrium and muscle wall. It was difficult to distinguish them from endometrial stromal sarcoma. The diagnosis and differential diagnosis should be made by immunohistochemical method.
【作者單位】: 南昌大學第一附屬醫(yī)院病理科;
【分類號】:R737.33
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