本文選題：宮頸癌 + 高遷移率族蛋白B　； 參考：《中國(guó)腫瘤生物治療雜志》2017年03期

【摘要】：目的:探討高遷移率族蛋白B1和N1(high mobility group B1 and N1,HMGB1 and HMGN1)在宮頸癌腫瘤細(xì)胞中的表達(dá)情況與腫瘤浸潤(rùn)淋巴細(xì)胞(tumor infiltrating lymphocytes,TILs)的關(guān)系。方法:收集2012年4月至2015年9月在天津醫(yī)科大學(xué)附屬腫瘤醫(yī)院就診的100例早期宮頸癌患者的術(shù)后腫瘤組織蠟塊標(biāo)本,其中Ⅰ和Ⅱ期各50例。免疫組織化學(xué)方法檢測(cè)腫瘤組織中HMGB1、HMGN1、CD3和CD8的表達(dá)。根據(jù)總體的染色強(qiáng)度將HMGB1和HMGN1分別分為高表達(dá)組和低表達(dá)組;根據(jù)有無細(xì)胞質(zhì)表達(dá)分別分為有胞質(zhì)表達(dá)組和無胞質(zhì)表達(dá)組。分別比較高、低表達(dá)組間及有、無胞質(zhì)表達(dá)組間腫瘤組織內(nèi)CD3~+和CD8~+細(xì)胞數(shù)。結(jié)果:腫瘤組織內(nèi)HMGB1和HMGN1的表達(dá)強(qiáng)度及有、無胞質(zhì)表達(dá)與患者年齡、FIGO分期、病理分級(jí)均沒有明顯相關(guān)性(P0.05);HMGB1與HMGN1兩者的胞質(zhì)表達(dá)呈正相關(guān)關(guān)系(P0.05)。HMGB1和HMGN1有胞質(zhì)表達(dá)組的CD3~+和CD8~+細(xì)胞較無胞質(zhì)表達(dá)組要高(P0.05)。結(jié)論:宮頸癌細(xì)胞HMGB1和HMGN1的胞質(zhì)表達(dá)與腫瘤組織內(nèi)高水平TILs相關(guān),這一發(fā)現(xiàn)有望為宮頸癌的免疫治療提供新的策略。
[Abstract]:Objective: to investigate the expression of high mobility group proteins B1 and N1 (high mobility group B1 and N1HMGB1 and HMGN1 in cervical cancer cells and the relationship between the expression of HMGB1 and HMGN1 and the expression of (tumor infiltrating lymphocytes in tumor infiltrating lymphocytes. Methods: from April 2012 to September 2015, the paraffin tissue specimens of 100 patients with early cervical cancer were collected from the affiliated Cancer Hospital of Tianjin Medical University, including 50 cases of stage 鈪，

本文編號(hào)：2090441