本文選題：宮頸癌 + 高遷移率族蛋白B�。� 參考：《中國腫瘤生物治療雜志》2017年03期

【摘要】：目的:探討高遷移率族蛋白B1和N1(high mobility group B1 and N1,HMGB1 and HMGN1)在宮頸癌腫瘤細胞中的表達情況與腫瘤浸潤淋巴細胞(tumor infiltrating lymphocytes,TILs)的關系。方法:收集2012年4月至2015年9月在天津醫(yī)科大學附屬腫瘤醫(yī)院就診的100例早期宮頸癌患者的術后腫瘤組織蠟塊標本,其中Ⅰ和Ⅱ期各50例。免疫組織化學方法檢測腫瘤組織中HMGB1、HMGN1、CD3和CD8的表達。根據總體的染色強度將HMGB1和HMGN1分別分為高表達組和低表達組;根據有無細胞質表達分別分為有胞質表達組和無胞質表達組。分別比較高、低表達組間及有、無胞質表達組間腫瘤組織內CD3~+和CD8~+細胞數。結果:腫瘤組織內HMGB1和HMGN1的表達強度及有、無胞質表達與患者年齡、FIGO分期、病理分級均沒有明顯相關性(P0.05);HMGB1與HMGN1兩者的胞質表達呈正相關關系(P0.05)。HMGB1和HMGN1有胞質表達組的CD3~+和CD8~+細胞較無胞質表達組要高(P0.05)。結論:宮頸癌細胞HMGB1和HMGN1的胞質表達與腫瘤組織內高水平TILs相關,這一發(fā)現有望為宮頸癌的免疫治療提供新的策略。
[Abstract]:Objective: to investigate the expression of high mobility group proteins B1 and N1 (high mobility group B1 and N1HMGB1 and HMGN1 in cervical cancer cells and the relationship between the expression of HMGB1 and HMGN1 and the expression of (tumor infiltrating lymphocytes in tumor infiltrating lymphocytes. Methods: from April 2012 to September 2015, the paraffin tissue specimens of 100 patients with early cervical cancer were collected from the affiliated Cancer Hospital of Tianjin Medical University, including 50 cases of stage 鈪，

本文編號：2090441