本文選題：排卵障礙性不孕 + 腎陽虛型不孕　； 參考：《湖北中醫(yī)藥大學》2014年碩士論文

【摘要】：目的：本研究通過對臨床病例資料收集統(tǒng)計，進行中藥人工周期聯(lián)合克羅米芬治療腎陽虛型排卵障礙性不孕癥的臨床觀察。在研究過程中，通過基礎體溫(BBT)測定、B超監(jiān)測卵泡發(fā)育情況、中醫(yī)癥狀等的觀察，與對照組(克羅米芬)相比較，評價其臨床療效。 方法：所有觀察病例均來源于武漢市中醫(yī)醫(yī)院2012年3月-2013年5月婦科門診的患者，根據(jù)病例的納入標準、排除標準以及中醫(yī)辨證標準，共收集62例作為觀察病例，按照隨機分配的原則，分為治療組(中藥人工周期聯(lián)合克羅米芬)32例和對照組(克羅米芬)30例。通過觀察兩組治療后的臨床總體療效結果、妊娠率、卵泡生長改善情況、性激素激素水平改善情況、中醫(yī)癥狀改善情況等，對上述資料進行數(shù)據(jù)分析和臨床研究。 結果：(1)治療后兩組總體療效結果的對比，治療組90.1%，對照組70.08%，經(jīng)統(tǒng)計學分析，兩組結果有明顯的統(tǒng)計學差異(P0.05)，治療組總體療效高與對照組；(2)治療后兩組妊娠率的對比，治療組37.5%，對照組20.0%，經(jīng)統(tǒng)計學分析，兩組結果有統(tǒng)計學差異(P0.05)，治療組妊娠率高于對照組；(3)治療前后，兩組中醫(yī)癥狀積分均較前有所下降，有統(tǒng)計學的差異(P0.05)，且治療組較對照組中醫(yī)癥狀積分的下降的情況表現(xiàn)的更加顯著；(4)治療前后兩組B超監(jiān)測卵泡直徑比較，兩組卵泡直徑均有所增長，且治療組卵泡生長更好，經(jīng)統(tǒng)計有顯著性差異(P0.05)；(5)治療后，兩組黃體期血清孕酮(P)和雌二醇(E2)結果比較，經(jīng)統(tǒng)計學分析，有明顯性差異(P0.05)，治療組黃體期P、E2的上升情況較對照組更明顯；(6)兩組患者在妊娠后先兆流產(chǎn)發(fā)生率進行比較，，治療組7.14%，對照組16.67%，經(jīng)過統(tǒng)計學分析，沒有顯著性差異(P0.05)；在治療期間，兩組病例的卵巢過度刺激征(OHSS)發(fā)生率進行比較，治療組6.30％，對照組26.67％，經(jīng)過數(shù)據(jù)的分析具有統(tǒng)計學差異(P0.05)。 結論：從治療后妊娠率，中醫(yī)癥狀積分的改善、卵泡發(fā)育大小及血清性激素情況等相關指標的統(tǒng)計結果來看，得出中藥人工周期聯(lián)合克羅米芬組治療腎陽虛型排卵障礙性不孕癥效果優(yōu)于克羅米芬對照組，并且能夠有效改善機體的整體狀況。
[Abstract]:Objective: to investigate the clinical effect of combination of traditional Chinese medicine and clomiphene in the treatment of ovulatory infertility with deficiency of kidney yang. In the course of the study, the basic body temperature (BBT) was measured, the follicle development was monitored by B-ultrasound, the symptoms of traditional Chinese medicine were observed, and compared with the control group (clomiphene), the clinical efficacy was evaluated. Methods: all the observed cases were from the outpatient department of gynecological department of Wuhan traditional Chinese Medicine Hospital from March 2012 to May 2013. According to the criteria of inclusion, exclusion and differentiation of symptoms and signs of TCM, 62 cases were collected as observation cases. According to the principle of random distribution, the patients were divided into treatment group (32 cases) and control group (30 cases). By observing the overall clinical curative effect, pregnancy rate, follicle growth improvement, sex hormone level improvement, TCM symptom improvement and so on, the above data were analyzed and studied. Results: (1) after treatment, there was a significant difference between the two groups (P0.05), the total curative effect of the treatment group was higher than that of the control group, (2) the pregnancy rate of the two groups was higher than that of the control group, and (2) the pregnancy rate of the two groups was higher than that of the control group. Treatment group 37.5, control group 20.0, the results of statistical analysis, the two groups have statistical differences (P0.05), the pregnancy rate in the treatment group is higher than the control group; (3) before and after treatment, the scores of TCM symptoms in the two groups are lower than before, There was statistical difference (P0.05), and the treatment group than the control group in the decline of the symptoms of more significant performance; (4) before and after the treatment of two groups of ultrasound monitoring follicle diameter, the two groups of follicle diameter increased, and the treatment group follicular growth better, After treatment with); (5, the results of progesterone (P) and estradiol (E 2) in the luteal phase of the two groups were compared, and the difference was significant (P0.05). The increase of serum progesterone (P) and estradiol (E 2) in the treatment group was more obvious than that in the control group. (6) the incidence of threatened abortion after pregnancy was compared between the two groups. The incidence of ovarian hyperstimulation (OHSS) was compared between the treatment group (7.14%) and the control group (16.67%) (P0.05). Treatment group 6.30 and control group 26.67, the data analysis has statistical difference (P0.05). Conclusion: according to the statistical results of pregnancy rate, improvement of TCM symptom score, follicular development and serum sex hormone status after treatment, The results showed that the efficacy of combination of traditional Chinese medicine and clomiphene in the treatment of ovulatory infertility with deficiency of kidney yang was better than that in clomiphene control group, and it could effectively improve the overall condition of the body.
【學位授予單位】：湖北中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R711.6

【參考文獻】

相關期刊論文 前10條

1 高慧;曹秀梅;王玉環(huán);林靜;劉玉蘭;;中藥保留灌腸加理療治療輸卵管阻塞性不孕癥臨床研究[J];中國醫(yī)藥導刊;2010年12期

2 靳艷玲;;中藥周期法治療子宮腺肌病的臨床體會[J];光明中醫(yī);2009年07期

3 于曉華;中醫(yī)治療排卵障礙性不孕的研究現(xiàn)狀[J];甘肅中醫(yī);2003年05期

4 朱蘭;郎景和;;子宮內(nèi)膜異位癥的免疫學研究進展[J];國外醫(yī)學.婦產(chǎn)科學分冊;2002年05期

5 陳秋梅;調(diào)經(jīng)孕育湯治療排卵障礙不孕癥的實驗研究[J];國外醫(yī)學(中醫(yī)中藥分冊);2002年04期

6 李鶯;;中藥人工周期療法治療月經(jīng)后期38例臨床觀察[J];浙江中醫(yī)藥大學學報;2012年09期

7 劉涓;;補腎調(diào)周法結合針灸治療黃體功能不全不孕癥60例[J];光明中醫(yī);2012年12期

8 隋曉東;曲秀芬;周微;李瑩;;排卵障礙性不孕的中醫(yī)藥治療進展[J];光明中醫(yī);2012年12期

9 李燦東,林雪娟,蘭啟防,黃熙理,高碧珍,丁杰;不孕癥肝郁病理的生殖內(nèi)分泌實質(zhì)研究[J];河南中醫(yī)學院學報;2004年06期

10 尤昭玲,楊正望,傅靈梅;多囊卵巢綜合征從腎虛血瘀調(diào)治的探討[J];湖南中醫(yī)學院學報;2005年01期

本文編號：2080950