本文選題：卵巢漿液性乳頭狀囊腺癌 + 生長抑素受體1��； 參考：《山西醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的:研究并討論生長抑素受體1(SSTR1)、生長抑素受體2(SSTR2)在卵巢漿液性乳頭狀囊腺癌中的表達(dá)、分布及相關(guān)性的研究。方法:該實(shí)驗(yàn)采用免疫組化SP法進(jìn)行SSTR1,SSTR2的檢測,以其染色細(xì)胞數(shù)所占比例作為生長抑素受體表達(dá)的計(jì)量標(biāo)準(zhǔn),描述SSTR1,SSTR2不同計(jì)量表達(dá)強(qiáng)度,采用SPSS17.0統(tǒng)計(jì)軟件分析29例患者SSTR1,SSTR2的表達(dá)強(qiáng)度,SSTR1,SSTR2在同一病人的腫瘤組織之中的表達(dá)分布特點(diǎn),以及SSTR1和SSTR2在表達(dá)上的相關(guān)性研究。結(jié)果:采用秩和檢驗(yàn)分析SSTR1和SSTR2兩組間的陽性表達(dá)情況,結(jié)果顯示:Z=5.0017,P0.001,按照α=0.05水準(zhǔn),即SSTR1和SSTR2的陽性表達(dá)強(qiáng)度差別有統(tǒng)計(jì)學(xué)意義,可以認(rèn)為兩種表達(dá)的陽性結(jié)果不同。SSTR1的陽性表達(dá)高于SSTR2。比較SSTR1表達(dá)陽性情況下SSTR2的陽性情況是否不同,檢驗(yàn)SSTR1和SSTR2的陽性表達(dá)情況是否一致,采用一致性檢驗(yàn);結(jié)果顯示:Z=0.444,P=0.6568,說明兩種SSTR表達(dá)的分布情況不具有一致性。將鏡下觀察計(jì)數(shù)染色細(xì)胞數(shù)資料用SPSS17.0統(tǒng)計(jì)軟件分析,其資料不服從正態(tài)分布資料,所以采用spearman秩相關(guān)分析,結(jié)果顯示r=-0.007,P=0.969,即SSTR1和SSTR2的表達(dá)強(qiáng)度無相關(guān)性。結(jié)論:1.SSTR1在卵巢漿液性乳頭狀囊腺癌中的高表達(dá)較SSTR2有顯著差異,說明SSTR1在該腫瘤的發(fā)生發(fā)展過程中是一個(gè)普遍現(xiàn)象,其SSTRl在OSPC的發(fā)展過程中很可能是一個(gè)潛在的提示性指標(biāo);2.SSTR1和SSTR2二者在卵巢漿液性乳頭狀囊腺癌中的表達(dá)無相關(guān)性;3.在對卵巢漿液性乳頭狀囊腺癌的研究中,SSTR1和SSTR2這兩種基因的表達(dá)分布不具一致性,說明其存在組織學(xué)分布上的異質(zhì)性,所以在針對藥物治療該種腫瘤時(shí),SSTR1、SSTR2應(yīng)作為獨(dú)立的因素進(jìn)行藥物靶點(diǎn)設(shè)計(jì)。
[Abstract]:Objective: to study the expression, distribution and correlation of somatostatin receptor 1 (SSTR1) and somatostatin receptor 2 (SSTR2) in ovarian serous papillary cystadenocarcinoma. Methods: SSTR1SSTR2 was detected by immunohistochemical SP method. The expression of somatostatin receptor was measured by the proportion of SSTR1SSTR2 staining cells, and the intensity of SSTR1SSTR2 expression was described. SPSS 17.0 statistical software was used to analyze the expression intensity of SSTR1 and SSTR2 in 29 patients and the expression distribution of SSTR1 and SSTR2 in tumor tissues of the same patient, and the correlation between SSTR1 and SSTR2 in the expression of SSTR1 and SSTR2. Results: the positive expression of SSTR1 and SSTR2 was analyzed by rank sum test. The results showed that the positive expression intensity of SSTR1 and SSTR2 was significantly different according to 偽 0.05 level. It can be concluded that the positive expression of SSTR1 is higher than that of SSTR2. The results showed that the positive expression of SSTR2 was different from that of SSTR1, and the positive expression of SSTR1 and SSTR2 was the same, and the results showed that the distribution of SSTR2 and SSTR1 were not consistent. The statistical software SPSS 17.0 was used to analyze the number of cells counted and stained under microscope. The data were not collected from normal distribution data, so spearman rank correlation analysis was used. The results showed that there was no correlation between the expression intensity of SSTR1 and SSTR2, and the correlation between the expression intensity of SSTR1 and SSTR2 was not found in the statistical software SPSS 17.0. The results showed that there was no correlation between SSTR1 and SSTR2. Conclusion the high expression of SSTR1 in ovarian serous papillary cystadenocarcinoma is significantly different from that in SSTR2, indicating that SSTR1 is a common phenomenon in the development of ovarian serous cystadenocarcinoma. The expression of SSTR1 and SSTR2 in ovarian serous papillary cystadenocarcinoma may be a potential indicator in the development of OSPC. 2. There is no correlation between SSTR1 and SSTR2 in ovarian serous papillary cystadenocarcinoma. In the study of ovarian serous papillary cystadenocarcinoma, the expression of SSTR1 and SSTR2 genes were not consistent, indicating the heterogeneity of histological distribution. Therefore, SSTR1 and SSTR2 should be used as independent factors in drug targeting.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R737.31

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 李霞;生長抑素的免疫調(diào)節(jié)作用[J];國外醫(yī)學(xué)(免疫學(xué)分冊);2004年03期

2 黃子健;黃璐;胥斯卡;梅雪婷;黃潔貞;喻玫;;生長抑素聯(lián)合順鉑抑制卵巢癌細(xì)胞的機(jī)制研究[J];婦產(chǎn)與遺傳(電子版);2013年02期

3 龍志祥;梁慶模;;生長抑素受體在腫瘤研究中的新進(jìn)展[J];實(shí)用癌癥雜志;2009年01期

4 馬莉;郭麗娜;武莎斐;任新瑜;;卵巢癌分型及其分子遺傳學(xué)研究進(jìn)展[J];生殖醫(yī)學(xué)雜志;2006年02期

5 華，

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