本文選題：優(yōu)生優(yōu)育 + TORCH　； 參考：《浙江大學(xué)》2017年碩士論文

【摘要】：計劃生育是我國的基本國策,優(yōu)生優(yōu)育是其具體內(nèi)涵的延伸,優(yōu)生優(yōu)育工作開展的好壞不但影響人口素質(zhì)的提高,而且與人口的發(fā)展息息相關(guān),對未來中華民族的社會發(fā)展具有舉足輕重的作用。產(chǎn)前篩查是優(yōu)生優(yōu)育工作中的重要措施,可以預(yù)防可能發(fā)生的出生缺陷。弓形蟲是剛地弓形蟲(Toxoplasma gondii)的簡稱,這種寄生蟲常常存在于人和動物的有核細(xì)胞內(nèi),可以導(dǎo)致人獸共患的寄生蟲病。當(dāng)宿主的免疫功能因為一些因素的影響受到抑制的時候,可能會引起組織和多臟器的損傷,引發(fā)獲得性弓形蟲病。這種病甚至在宿主的免疫功能衰竭時迅速播散,造成致死性感染。如果弓形蟲通過孕婦的胎盤傳給胎兒,會使胎兒罹患先天性弓形蟲病。所以研究弓形蟲病的篩查,對優(yōu)生優(yōu)育工作具有重要意義。TORCH是幾種較常見并且重要的子宮內(nèi)感染因素的縮寫�！癟”是弓形蟲的縮寫,“0”是其他病原微生物的縮寫,“R”是風(fēng)疹病毒的縮寫,“C”是巨細(xì)胞病毒的縮寫,“H”是單純皰疹病毒的縮寫。TORCH感染可導(dǎo)致新生兒多器官的損害,甚至引發(fā)一系列嚴(yán)重的后遺癥,對新生兒的健康帶來危害。所以,針對優(yōu)生優(yōu)育工作進(jìn)行相應(yīng)的血清學(xué)篩查不但重要而且非常必要。臨床醫(yī)務(wù)工作者應(yīng)該積極開展相應(yīng)的血清學(xué)篩查,對不良妊娠做到“早發(fā)現(xiàn)、早處理”,以降低病殘兒的出生率,對出生人口素質(zhì)的提高做好保障�，F(xiàn)階段,在我國的早期篩查中,廣泛應(yīng)用ELISA酶聯(lián)免疫檢測技術(shù),對人體血清中的特異性IgM、IgG抗體進(jìn)行檢測。其中IgM為早期感染的重要指標(biāo),對新生兒的健康具有非常重要的意義,因此IgM的檢測尤為重要。對胎兒宮內(nèi)感染的診斷來說,檢測胎盤中的特異性IgM可靠性更高。臨床廣泛采用的ELISA酶聯(lián)免疫診斷技術(shù)具有靈敏度高、特異性好、試劑穩(wěn)定及成本低廉等優(yōu)點。本文研制的弓形蟲免疫球蛋白M抗體酶聯(lián)免疫檢測試劑盒利用捕獲法來定性檢測人血清或血漿中的弓形蟲免疫球蛋白M抗體。這對于通過血清學(xué)研究來判斷人體對弓形蟲感染的免疫情況以及是否初次感染有著重要的意義。
[Abstract]:Family planning is the basic national policy of our country, and eugenics are the extension of its specific connotations. The quality of the work of eugenics and eugenics not only affects the improvement of the quality of the population, but also is closely related to the development of the population. It will play an important role in the future social development of the Chinese nation. Prenatal screening is an important measure to prevent possible birth defects. Toxoplasma gondii (Toxoplasma gondii) is short for Toxoplasma gondii. Toxoplasma gondii often exist in the nucleated cells of human and animal, which can lead to zoonotic parasite disease. When the host's immune function is inhibited by some factors, it may cause tissue and multiple organ damage and lead to acquired toxoplasmosis. The disease spreads rapidly even when the host's immune system fails, causing fatal infections. If Toxoplasma gondii passes through the placenta of a pregnant woman, it can cause congenital toxoplasmosis. So to study the screening of Toxoplasma gondii is of great significance to eugenics and eugenics. Torch is the abbreviation of several common and important intrauterine infection factors. "T" is the abbreviation of Toxoplasma gondii and "0" is the abbreviation of other pathogenic microorganisms. "R" is the abbreviation of rubella virus, "C" is the abbreviation of cytomegalovirus, "H" is the abbreviation of herpes simplex virus. It is harmful to the health of newborns. Therefore, the corresponding serological screening for eugenic and eugenic work is not only important but also very necessary. In order to reduce the birth rate of sick and disabled children and improve the quality of birth population, clinical medical workers should actively carry out serological screening and do "early detection and early treatment" of bad pregnancy. At present, Elisa enzyme-linked immunosorbent assay (Elisa) is widely used in early screening in China to detect the specific IgG antibody in human serum. IgM is an important indicator of early infection, which is of great significance to the health of newborns, so the detection of IgM is particularly important. Detection of specific IgM in the placenta is more reliable for the diagnosis of fetal intrauterine infection. Enzyme linked immunosorbent assay (Elisa), which is widely used in clinic, has the advantages of high sensitivity, good specificity, stable reagent and low cost. The enzyme linked immunosorbent assay kit of Toxoplasma gondii immunoglobulin M antibody developed in this paper was used to qualitatively detect Toxoplasma immunoglobulin M antibody in human serum or plasma by capture method. This is of great significance to determine the immune status of Toxoplasma gondii infection and whether it is infected for the first time through serological research.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R446.6;R714.25

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本文編號：2062361