本文選題：知柏更安湯 + 克齡蒙��； 參考：《山東中醫(yī)藥大學》2014年碩士論文

【摘要】：目的：比較中藥知柏更安湯聯(lián)合克齡蒙及單用克齡蒙治療陰虛火旺型絕經綜合征的作用差別，確立陰虛火旺型絕經綜合征中西醫(yī)結合治療方案。并且通過觀察中藥知柏更安湯聯(lián)合克齡蒙治療陰虛火旺型絕經綜合征的臨床療效，探討其作用機理，為推廣應用提供理論依據。 方法：篩選陰虛火旺型絕經綜合征患者60例，隨機分為治療組30例：服用知柏更安湯的同時，服用克齡蒙，共治療3個療程。對照組30例：服用克齡蒙治療3個療程。觀察兩組用藥3個療程后的改良Kupperman評分，中醫(yī)證候評分，和血清促卵泡激素(FSH)，黃體生成素(LH)，雌二醇(E2)的變化。 結果：1.臨床療效比較：治療后治療組總有效率為93.33%，對照組總有效率為70.00%，兩組組間比較，X2＝4.007，P＝0.045＜0.05，差異有統(tǒng)計學意義，，說明治療組優(yōu)于對照組。2.中醫(yī)證候療效比較：治療后治療組總有效率為96.67%，對照組總有效率為73.33%，兩組組間比較，X2＝4.242，P＝0.039＜0.05，差異有統(tǒng)計學意義，說明治療組優(yōu)于對照組。3.治療組與對照組組內比較，改良Kupperman評分、中醫(yī)證候評分治療后較治療前均降低，差異均有高度統(tǒng)計學意義(P＜0.01)；組間比較,差異均有高度統(tǒng)計學意義(P＜0.01)。4.治療前,兩組患者E2、FSH、LH比較，差異均無統(tǒng)計學意義(P＞0.05)，具有可比性。治療后，兩組E2較治療前升高，差異有高度統(tǒng)計學意義(P＜0.01)。FSH、LH較治療前降低，差異均有高度統(tǒng)計學意義(P＜0.01)。兩組組間比較，E2差異有統(tǒng)計學意義(P＜0.05)，F(xiàn)SH、LH差異均無統(tǒng)計學意義(P＞0.05)。 結論：在用中藥知柏更安湯治療的基礎上聯(lián)合克齡蒙治療陰虛火旺型絕經綜合征具有更好的臨床療效，能夠明顯改善中醫(yī)證候，其作用機制與其從整體上調整神經內分泌紊亂有關，為本病的中西醫(yī)結合治療及進一步研究提供了一定的客觀依據，值得在臨床中推廣應用。
[Abstract]:Objective: to compare the effect of Zhibaiganan decoction combined with Kelingmeng and Kelingmeng alone in the treatment of Yin-deficiency Huowang menopausal syndrome, and to establish the integrated treatment scheme of traditional Chinese and western medicine for Yin-deficiency Huo-wang menopausal syndrome. And by observing the clinical effect of Zhibaiganan decoction combined with Kelingmeng in treating menopausal syndrome with yin deficiency and fire, the mechanism of its action was discussed, and the theoretical basis for popularization and application was provided. Methods: a total of 60 cases of Yin-deficiency and Huo-wang type menopause syndrome were selected and randomly divided into treatment group (n = 30): taking Zhibengan decoction and taking Ke Ling Meng for 3 courses of treatment. The control group (n = 30) was treated with Kelingmen for 3 courses. The changes of modified Kupperman score, TCM syndrome score and serum follicle stimulating hormone (FSH), luteinizing hormone (LHN) and estradiol (E _ 2) were observed in the two groups after 3 courses of treatment. The result is 1: 1. Comparison of clinical efficacy: the total effective rate of the treatment group was 93.33, the total effective rate of the control group was 70.005, and the comparison between the two groups was X24.007P0. 045 < 0. 05, the difference was statistically significant, indicating that the treatment group was superior to the control group. 2. Comparison of TCM syndromes efficacy: after treatment, the total effective rate of the treatment group was 96.677.The total effective rate of the control group was 73.33.The difference between the two groups was statistically significant, indicating that the treatment group was superior to the control group (.3). Compared with the control group, the modified Kupperman score and TCM syndrome score decreased after treatment (P < 0.01), and there were significant differences between the two groups (P < 0.01). Before treatment, there was no significant difference between the two groups (P > 0.05). After treatment, E _ 2 in the two groups was higher than that before treatment, and the difference was statistically significant (P < 0.01). FSHLH was lower than that before treatment, and the difference was statistically significant (P < 0.01). There was no significant difference in E _ 2 between the two groups (P < 0.05) and there was no significant difference in FSH LH between the two groups (P > 0.05). Conclusion: on the basis of traditional Chinese medicine Zhibogenan decoction combined with Kelingmeng in the treatment of Yin-deficiency and Huo-Wang type menopausal syndrome, it has better clinical effect and can obviously improve TCM syndromes. The mechanism is related to the adjustment of neuroendocrine disorder, which provides a certain objective basis for the treatment and further study of this disease, and is worth popularizing in clinic.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R711.75

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