本文選題：體外受精胚胎移植 + 預(yù)測模型　； 參考：《廣東醫(yī)學(xué)》2017年09期

【摘要】：目的探討與體外受精胚胎移植妊娠成功率相關(guān)的臨床因素,并在此基礎(chǔ)上建立妊娠預(yù)測模型。方法選擇950例新鮮胚胎移植周期接受體外受精或單精子卵胞漿內(nèi)注射-胚胎移植(IVF/ICSI-ET)技術(shù)助孕治療的患者,共計1 192個周期。去除取消移植的、數(shù)據(jù)丟失的、失訪的和補(bǔ)救ICSI等情況的共242個周期,剩余950個周期納入分析。按是否妊娠成功分為:成功組624例,妊娠成功;失敗組326例,妊娠不成功。比較兩組患者的年齡、病因、卵巢功能水平、促性腺激素(Gn)應(yīng)用情況、人絨毛膜促性腺激素(HCG)日性激素水平、取卵情況以及胚胎相關(guān)情況等因素的差異。通過多因素logistic回歸分析,對妊娠成功可能產(chǎn)生影響的8個特征性因素進(jìn)行多因素分析。結(jié)果全組妊娠成功率為65.68%。與失敗組相比,成功組的年齡、基礎(chǔ)卵泡刺激素(FSH)、基礎(chǔ)竇卵泡數(shù)、周期次數(shù)、Gn劑量、Gn時間、HCG日內(nèi)膜厚度、HCG日黃體酮(P)水平、卵子數(shù)、受精率、優(yōu)質(zhì)胚胎數(shù)差異有統(tǒng)計學(xué)意義(P0.05)。多因素分析顯示不孕癥患者的年齡、HCG日P水平及優(yōu)質(zhì)胚胎數(shù)是移植妊娠成功的獨立相關(guān)因素(P0.05)。結(jié)論 IVF/ICSI-ET治療中影響妊娠成功率的臨床因素是多方面的。
[Abstract]:Objective to investigate the clinical factors related to the success rate of in vitro fertilization and embryo transfer (IVF) and to establish a pregnancy prediction model. Methods 950 patients with IVF / ICSI-ETT in vitro fertilization or intracytoplasmic injection-embryo transfer (ICSI-ETT) were selected for 1 192 cycles. A total of 242 cycles of canceling transplantation, data loss, missing access and remediation ICSI were removed, and the remaining 950 cycles were included in the analysis. According to whether pregnancy was successful, 624 cases in successful group and 326 cases in failed group were divided into two groups: successful group (624 cases) and failed group (326 cases). The age, etiology, ovarian function, gonadotropin (Gn) application, daily HCG level, egg extraction and embryo related factors were compared between the two groups. By multivariate logistic regression analysis, 8 characteristic factors that may affect pregnancy success were analyzed. Results the success rate of pregnancy was 65.68%. Compared with the failed group, there were significant differences in age, basal follicle stimulating hormone (FSHN), basal antral follicle (FSH), number of basal antral follicles (FSH), number of cycles (G n), endometrial thickness of HCG day and progesterone (P) level, egg number, fertilization rate and number of high quality embryos in the successful group. Multivariate analysis showed that the age of infertile patients with HCG and the number of high quality embryos were independent factors related to the success of pregnancy transfer. Conclusion the clinical factors influencing pregnancy success rate in IVF-ICSI-ET therapy are various.
【作者單位】： 珠海市婦幼保健院生殖中心;
【分類號】：R714.8

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本文編號：2014058