發(fā)布時間：2018-06-05 02:19

  本文選題：妊娠期糖尿病 + 胰島素抵抗　； 參考：《山東醫(yī)藥》2017年30期

【摘要】：目的探討妊娠期糖尿病(GDM)患者血清分泌型卷曲相關蛋白5(Sfrp5)、血漿Fox基因家族成員FoxM1水平與胰島素抵抗的關系。方法選擇GDM患者56例(GDM組)及正常產(chǎn)婦56例(對照組),采集空腹靜脈血檢測空腹胰島素(FINS)、空腹血糖(FPG),并計算胰島素抵抗指數(shù)(HOMA-IR),分別采用ELFSA法和實時熒光PCR法檢測血清Sfrp5水平及血漿FoxM1 mRNA水平,并分析其與HOMA-IR的相關性。結(jié)果 GDM組血清FPG、FINS、HOMA-IR和血漿FoxM1 mRNA水平均高于對照組(P均0.05),GDM組血清Sfrp5水平低于對照組(P0.05)。GDM患者HOMA-IR與血清Sfrp5水平呈負相關(r=-0.571,P0.01),與血漿FoxM1 mRNA水平呈正相關(r=0.613,P0.01)。結(jié)論 GDM患者血清Sfrp5水平降低且與胰島素抵抗呈負相關,血漿FoxM1水平增加且與胰島素抵抗呈正相關。
[Abstract]:Objective to investigate the relationship between insulin resistance and serum secretory crimp associated protein 5 Sfrp5, FoxM1 level of plasma Fox gene family in patients with gestational diabetes mellitus (GDM). Methods 56 patients with GDM and 56 normal women (control group) were selected. Fasting venous blood samples were collected to detect fasting insulin and fasting blood glucose. The insulin resistance index (HOMA-IRN) was calculated by ELFSA method and real-time fluorescence PCR method, respectively. Serum Sfrp5 level and plasma FoxM1 mRNA level, The correlation with HOMA-IR was analyzed. Results the levels of serum HOMA-IR and plasma FoxM1 mRNA in GDM group were significantly higher than those in control group (P < 0.05). There was a negative correlation between HOMA-IR and serum Sfrp5 level in GDM group, and there was a positive correlation between HOMA-IR level and plasma FoxM1 mRNA level. Conclusion the level of serum Sfrp5 in patients with GDM was decreased and negatively correlated with insulin resistance, and the level of plasma FoxM1 was increased and positively correlated with insulin resistance.
【作者單位】： 蘇州大學附屬第一醫(yī)院;
【基金】：江蘇省科技計劃發(fā)展項目(BK2014189)
【分類號】：R714.256

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本文編號：1980000