本文選題：經(jīng)驗(yàn)引導(dǎo)調(diào)強(qiáng)計(jì)劃 + 常規(guī)調(diào)強(qiáng)計(jì)劃　； 參考：《中華腫瘤防治雜志》2015年23期

【摘要】：目的通過(guò)比較宮頸癌經(jīng)驗(yàn)引導(dǎo)調(diào)強(qiáng)(knowledge-based intensity-modulated radiotherapy,K-IMRT)與常規(guī)調(diào)強(qiáng)(conventional intensity-modulated radiotherapy,C-IMRT)在計(jì)劃靶區(qū)(planning target volume,PTV)和危及器官(organ at risk,OAR)的劑量學(xué)差異,探討基于先驗(yàn)知識(shí)的宮頸癌調(diào)強(qiáng)計(jì)劃自動(dòng)優(yōu)化的可行性。方法選取山東省腫瘤醫(yī)院2014-05-01-2014-09-01宮頸癌術(shù)后患者10例,進(jìn)行CT模擬定位、靶區(qū)和危及器官的勾畫(huà),用Eclipse 13.0治療計(jì)劃系統(tǒng)基于同一CT圖像進(jìn)行K-IMRT和C-IMRT調(diào)強(qiáng)計(jì)劃設(shè)計(jì)。在95%體積的PTV達(dá)到處方劑量的條件下,比較兩種調(diào)強(qiáng)計(jì)劃的劑量體積直方圖(dose volume histogram,DVH),分析靶區(qū)均勻性指數(shù)(homogeneity index,HI)、適形度指數(shù)(conformity index,CI)、OAR受照劑量和計(jì)劃時(shí)間。結(jié)果 K-IMRT計(jì)劃與C-IMRT計(jì)劃在靶區(qū)受照劑量、HI和CI差異均無(wú)統(tǒng)計(jì)學(xué)意義,P0.05。膀胱V30、左股骨頭V40、右股骨頭V20、V30和D50K-IMRT計(jì)劃明顯優(yōu)于C-IMRT計(jì)劃,差異有統(tǒng)計(jì)學(xué)意義,P0.05。膀胱V20、V30和D50,直腸V20、V30和V50及左右股骨頭受照劑量均值都低于C-IMRT計(jì)劃。計(jì)劃時(shí)間K-IMRT明顯縮短。結(jié)論宮頸癌術(shù)后基于先驗(yàn)知識(shí)的調(diào)強(qiáng)計(jì)劃自動(dòng)優(yōu)化結(jié)果可以達(dá)到與C-IMRT計(jì)劃相似的靶區(qū)劑量分布,能夠降低危及器官的受照受量,在計(jì)劃優(yōu)化應(yīng)用中是可行的。
[Abstract]:Objective to compare the dosimetric differences between Knowledge-based intensity-modulated radiotherapyn K-IMRT (Knowledge-based intensity-modulated radiotherapyn) and C-IMRT (conventional intensity modulated intensity-modulated radiotherapyn) in the planning target area of cervical cancer, and to explore the feasibility of automatic optimization of cervical cancer intensity modulation plan based on prior knowledge. Methods Ten patients with cervical cancer were selected from 2014-05-01-2014-09-01 cervical cancer surgery in Shandong Cancer Hospital. Ct simulation location, target area and dangerous organs were delineated. The K-IMRT and C-IMRT intensity modulation plans were designed with Eclipse 13.0 treatment planning system based on the same CT images. Under the condition that 95% volume PTV reached the prescribed dose, the dose volume histogram and dose volume histogramme of the two intensity modulated plans were compared, and the homogeneity index and conformity index were analyzed. Results there was no significant difference in HI and CI between K-IMRT program and C-IMRT plan in target area (P 0.05). Bladder V30, left femoral head V40, right femoral head V20 V30 and D50K-IMRT plan were significantly superior to C-IMRT plan (P 0.05). The mean values of V30 and D50 in bladder, V30 and V50 in rectum, and in the left and right femoral head were lower than those in C-IMRT plan. The planning time K-IMRT was shortened obviously. Conclusion the automatic optimization results of intensity modulation plan based on prior knowledge after cervical cancer operation can reach the dose distribution of target area similar to that of C-IMRT plan, and can reduce the exposure to radiation of endangered organs, which is feasible in the application of planning optimization.
【作者單位】： 濟(jì)南大學(xué)·山東省醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與生命科學(xué)學(xué)院;山東省腫瘤醫(yī)院物理室;萊蕪市人民醫(yī)院放療科;
【基金】：山東省自然科學(xué)基金(ZR2013HL044)
【分類號(hào)】：R737.33
，

本文編號(hào)：1972038