本文選題：頸項透明層 + 胎兒��； 參考：《新疆醫(yī)科大學》2014年碩士論文

【摘要】：目的：探討漢族和維族正常單胎胎兒頸項透明層(nuchal translucency, NT)是否存在差異性及其正常值范圍并評估頸項透明層聯(lián)合孕婦血清學篩查胎兒染色體異常的臨床價值。方法：選取在我院行NT檢查的正常單胎8161例,其中漢族5025例,維族3136例對不同孕周維族和漢族胎兒NT進行分析,采用線性回歸計算不同孕周胎兒的NT厚度的第5%、50%、95%位數(shù),并對3106名孕11-13+6周行胎兒NT測量且另于孕14-20周行血清游離雌三醇(UE3)、甲胎蛋白(AFP)、游離絨毛膜促性腺激素β亞基(Free β?-HCG)檢測的結(jié)果與妊娠結(jié)局相對照,分析頸項透明層和孕婦血清學及其與胎兒染色體的關(guān)系,并建立受試者工作特性曲線(ROC曲線)。結(jié)果：孕11-13+6周漢族與維族相同孕周的孕婦年齡及胎兒NT厚度間差異均無統(tǒng)計學意義(P0.05),孕13+6周漢族與維族胎兒的第95%位數(shù)均為0.22cm,染色體異常胎兒的NT及孕婦血清學與染色體正常組胎兒比較,差異均有統(tǒng)計學意義(P0.05),以胎兒頸項透明層0.22cm為鑒別胎兒染色體異常的診斷界點,則診斷敏感度、特異度分別為77.43%、99.05%,以孕婦血清學超過1/270為鑒別胎兒染色體異常的診斷界點,則診斷敏感度、特異度分別為85.71%、95.85%,兩者聯(lián)合診斷的敏感度、特異度分別為100%、99.7%,差異均有統(tǒng)計學意義(P＜0.05), ROC曲線下面積(area under the curve, AUC)四者分別為0.830、0.866、0.903、0.995。結(jié)論：妊娠11-13+6周,漢族和維族胎兒NT值不存在民族差異性,就本地區(qū)而言把NT正常值設定在0.22cm是行之有效的,胎兒頸項透明層聯(lián)合孕婦血清學對胎兒染色體異常及其他畸形的篩查優(yōu)于單獨應用。
[Abstract]:Objective: To investigate the difference and normal range of nuchal translucency (NT) in the normal single fetus of the Han and Uygur single fetuses and to evaluate the clinical value of the screening of abnormal fetal chromosomes by the clear layer of the cervical layer combined with pregnant women. Methods: 8161 cases of normal single fetus were selected in our hospital with NT examination, of which 5025 cases were Han and vitamin D. The NT of the Uygur and Han fetuses of different gestational weeks was analyzed in 3136 ethnic groups. The 5%, 50% and 95% figures of the NT thickness of different gestational fetus were calculated by linear regression, and the fetal NT was measured in 3106 pregnancy 11-13+6 weeks and the serum free female three alcohol (UE3), AFP and free chorionic gonadotropin beta subunit (Free beta -HCG) were performed at the 14-20 week of pregnancy. The results of the test were compared with the pregnancy outcome, and the relationship between the clear layer of the neck and the serology of pregnant women and their fetal chromosomes was analyzed, and the working characteristic curves of the subjects (ROC curve) were established. The results showed that there was no significant difference between the pregnant women of the Han and the Uygurs at the same pregnancy 11-13+6 weeks and the NT thickness of the fetus (P0.05), and the Han nationality was pregnant 13+6 weeks. The 95% digit number of the Uygur fetus was 0.22cm, the NT of abnormal fetal chromosomes and the maternal serology and the normal chromosome group were statistically significant (P0.05). The diagnostic sensitivity of the fetal neck transparent layer 0.22cm was the diagnostic point of fetal chromosomal abnormalities, and the specificity of the diagnostic sensitivity was 77.43%, 99.05%, respectively. The diagnostic sensitivity of more than 1/270 to identify fetal chromosomal abnormalities was 85.71% and 95.85%, respectively. The sensitivity of the combined diagnosis was 100% and 99.7% respectively (P < 0.05). The area under the ROC curve (area under the curve, AUC) four were 0.830,0.866,0.903,0.995. knots, respectively. On the 11-13+6 weeks of pregnancy, the NT values of the Han and Uygur fetus do not exist in national differences. It is effective to set the normal value of NT in the region in the region of 0.22cm. The screening of fetal neck translucent layer and pregnant women's serology is superior to the screening of fetal chromosomal abnormalities and other malformations.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R714.5

【參考文獻】

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本文編號：1971907