本文選題：人絨毛膜促性腺激素 + 基因多態(tài)性�。� 參考：《實用婦產(chǎn)科雜志》2017年03期

【摘要】：復發(fā)性流產(chǎn)(RPL)是育齡期婦女中一種常見導致不育的疾病,患者臨床表現(xiàn)為孕早期連續(xù)發(fā)生3次及其以上次數(shù)的自然流產(chǎn)。引起RPL的病因涉及許多方面,具體的致病機制尚未完全闡明。隨著對RPL研究的深入,發(fā)現(xiàn)眾多因素的綜合作用造成了RPL的發(fā)生,人絨毛膜促性腺激素(HCG)水平對妊娠結(jié)局有重要影響,染色體異常中的編碼HCG表達的基因絨毛膜促性腺激素基因(CGB)多態(tài)性可能與RPL有關。CGB5和CGB8的基因單核苷酸多態(tài)性和拷貝數(shù)變異等可能導致HCG分泌異常引起流產(chǎn),也有研究顯示CGB5、CGB8啟動子中的堿基變異可能降低流產(chǎn)的風險。臨床上適當補充HCG可以用于治療RPL,但現(xiàn)有研究并不多,還需要大樣本量的進一步探討。
[Abstract]:Recurrent abortion (RPLs) is a common disease in women of childbearing age that leads to infertility. The clinical manifestation of RPLs is the spontaneous abortion which occurs three times or more in the early stage of pregnancy. The etiology of RPL is involved in many aspects, and the specific pathogenesis has not been fully elucidated. With the further study of RPL, it is found that many factors cause the occurrence of RPL, and the level of human chorionic gonadotropin (HCG) plays an important role in the outcome of pregnancy. The polymorphisms of chorionic gonadotropin (HCG) gene encoding HCG expression in chromosomal abnormalities may be associated with RPL. CGB5 and CGB8 gene single nucleotide polymorphisms and copy number variations may lead to miscarriage due to abnormal HCG secretion. Studies have also shown that base mutations in the CGB5 or CGB8 promoter may reduce the risk of abortion. Proper supplement of HCG in clinic can be used to treat RPLs, but there are not many existing researches, which need to be further discussed in large sample size.
【作者單位】： 同濟大學附屬第一婦嬰保健院;
【基金】：2014年度上海市市級醫(yī)院新興前沿技術聯(lián)合攻關項目(編號:SHDC12014129) 2014年度上海市醫(yī)學引導類科技項目(編號:14411966600)
【分類號】：R714.21

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本文編號：1950122