本文選題：子癇前期 + 胎盤(pán)sEng�。� 參考：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:通過(guò)對(duì)我院漢族及哈薩克族子癇前期(Preeclampsia,PE)妊娠婦女胎盤(pán)組織中的sEng的信使核糖核酸(mRNA)的表達(dá)程度的測(cè)定,研究漢族及哈薩克族民族PE妊娠期婦女之間胎盤(pán)中sEng的mRNA的測(cè)定值之間的差異以及孕婦相關(guān)指標(biāo)的差異。方法:選取2016年1月至6月在我院即新疆醫(yī)科大學(xué)的第一臨床醫(yī)學(xué)院入住并生產(chǎn)的漢族及哈薩克族子癇前期妊娠期婦女各30例與同期無(wú)妊娠合并癥的妊娠期婦女各30例。正常妊娠組中設(shè)漢族為A1組,哈薩克族為A2組;PE組中設(shè)漢族PE妊娠期婦女為B1組,哈薩克族PE妊娠期婦女為B2組,測(cè)定漢族及哈薩克族兩大組妊娠期婦女的娩出的胎盤(pán)組織中sEng的信使核糖核酸的表達(dá)程度,同時(shí)檢測(cè)各組漢族與哈薩克族兩組妊娠婦女血液中的PE相關(guān)的生化指標(biāo):尿酸的值、血清白蛋白的值、甘油三酯、高密度脂蛋白(HDL)水平。結(jié)果:1.A1組與A2組、B1組與B2組胎盤(pán)組織中在sEng的mRNA表達(dá)程度的不同在統(tǒng)計(jì)學(xué)上有不同(P0.05)。A2組與B2胎盤(pán)sEng的mRNA表達(dá)水平差異不具有統(tǒng)計(jì)學(xué)意義(P0.05)。2.A1組與A2組、B1組與B2組、哈薩克族無(wú)合并癥妊娠婦女和哈薩克族PE妊娠婦女組在最終的生產(chǎn)孕周數(shù)上的不同有統(tǒng)計(jì)學(xué)意義(P0.05)。3.A1組與A2組、B1組與B2組、血清中尿酸、甘油三酯水平、HDL、白蛋白水平在無(wú)合并癥妊娠婦女和PE妊娠婦女的血液中的測(cè)定值之間的不同有統(tǒng)計(jì)學(xué)意義(P0.05),哈薩克族無(wú)合并癥的妊娠婦女和漢族的無(wú)合并癥妊娠婦女在血清白蛋白上的不同有統(tǒng)計(jì)學(xué)意義(P0.001)。結(jié)論:我院的妊娠期婦女在胎盤(pán)sEng的mRNA表達(dá)水平上,漢族和哈薩克族無(wú)合并癥妊娠婦女和PE妊娠婦女之間有差異,漢族PE和哈薩克族PE之間無(wú)差異;哈薩克族子癇前期孕婦白蛋白、新生兒分娩的體重、生產(chǎn)的孕周均較漢族水平降低,在臨床工作中應(yīng)著重注意對(duì)哈薩克族孕婦進(jìn)行更詳細(xì)產(chǎn)前檢查和孕期督導(dǎo)。
[Abstract]:Objective: to determine the expression of sEng mRNA in placenta of preeclampsia preeclampsis (PEP) pregnant women in our hospital. To study the difference of mRNA of sEng in placenta between pregnant women of Han nationality and Kazak nationality of PE and the difference of related indexes of pregnant women. Methods: from January to June 2016, 30 pregnant women of Han nationality and 30 pregnant women of Kazak nationality who were admitted to the first Clinical Medical College of Xinjiang Medical University from January to June 2016 and 30 pregnant women without complications of pregnancy in the same period were selected. In normal pregnancy group, Han nationality was set up as A1 group, Kazak group as A2 group, PE group as B1 group, and Kazak group as B2 group. The expression of sEng mRNA in placenta of pregnant women of Han nationality and Kazak nationality was measured, and the value of uric acid in the blood of pregnant women of Han nationality and Kazak nationality was also detected. Serum albumin, triglyceride, high density lipoprotein (HDL) levels. Results there were statistical differences in the expression of mRNA in sEng between group A1 and group A2 in placenta of group B _ 1 and B _ 2. There was no statistical difference in the expression of mRNA between group A _ 2 and group B _ 2. There was no significant difference between group A _ 1 and group A _ 2, group B _ 1 and group B _ 2, there was no significant difference in mRNA expression between group A _ 1 and group A _ 2. There were significant differences in the number of final gestational weeks between Kazak women without complications and Kazakh PE pregnant women. There were significant differences in serum uric acid levels between group A 1 and group A 2, group B 1 and group B2, respectively. The difference of serum levels of triglyceride and albumin in the blood of pregnant women without complications and women with PE has statistical significance (P 0.05), pregnant women of Kazak nationality without complications and women without complications of Han nationality have no complications of pregnancy. The difference in serum albumin in women was statistically significant (P 0.001). Conclusion: the expression of mRNA in placental sEng of pregnant women in our hospital is different between Han and Kazakh pregnant women without complication and PE pregnancy, but there is no difference between Han nationality PE and Kazakh PE. Albumin of Kazakh preeclampsia pregnant women, birth weight of newborns and gestational weeks of birth were all lower than those of Han nationality. In clinical work, more detailed prenatal examination and pregnancy supervision should be paid more attention to in the clinical work of Kazakh preeclampsia pregnant women.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R714.244

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