發(fā)布時(shí)間：2018-05-22 14:31

  本文選題：妊娠 + 系統(tǒng)性紅斑狼瘡��； 參考：《實(shí)用婦產(chǎn)科雜志》2015年04期

【摘要】：目的:探討妊娠合并系統(tǒng)性紅斑狼瘡(SLE)患者孕期病情活動與否對母嬰結(jié)局的影響。方法:回顧性分析2007年1月至2013年12月北京大學(xué)第三醫(yī)院收治的42例妊娠合并SLE患者的臨床資料,SLE病情活動組23例,非活動組19例。結(jié)果:1除外流產(chǎn),SLE病情活動組終止妊娠的孕周較非活動組小(36.2±2.8周vs 38.1±0.7周,P=0.021),早產(chǎn)率較非活動組高(46.7%vs 6.7%,P=0.035),活產(chǎn)兒平均體重低于非活動組(2456.2±754.6 g vs 2956.3±420.0 g,P=0.048)。2各類合并癥中,妊娠合并狼瘡腎炎發(fā)生率最高(19.0%),妊娠期高血壓疾病在SLE病情活動組發(fā)生率明顯高于非活動組(34.8%vs 5.3%,P=0.027),其他如妊娠期糖尿病、胎兒生長受限、羊水少、胎膜早破、前置胎盤等并發(fā)癥兩組間比較差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。3孕前每天激素用量10 mg組流產(chǎn)及早產(chǎn)發(fā)生率明顯高于每天激素用量≤10 mg組(55.6%vs 9.5%,75.0%vs 5.3%,P均0.05)。結(jié)論:SLE患者妊娠時(shí)發(fā)生妊娠期高血壓疾病、早產(chǎn)、低出生體重兒的幾率在SLE病情活動時(shí)明顯增加,建議在病情穩(wěn)定半年以上或疾病緩解期受孕,控制孕前激素用量。孕前激素用量10mg的患者流產(chǎn)及早產(chǎn)率高。
[Abstract]:Objective: to investigate the effect of maternal and infant outcome in pregnancy with systemic lupus erythematosus (SLE). Methods: the clinical data of 42 pregnant women with SLE were retrospectively analyzed from January 2007 to December 2013 in the third Hospital of Peking University. 23 cases in active group and 19 cases in inactive group. Results the gestational weeks of termination of pregnancy in active group were 36.2 鹵2.8 weeks vs 38.1 鹵0.7 weeks, and the preterm delivery rate was 46.7% vs 6.7%. The average body weight of live infants was lower than that of inactive group (2456.2 鹵754.6 g vs 2956.3 鹵420.0 g P0. 048). The incidence of pregnancy with lupus nephritis was the highest (19.0%). The incidence of hypertensive disorder complicating pregnancy in the active group of SLE was significantly higher than that in the inactive group (34.8 vs 5.3%). Other factors such as gestational diabetes mellitus, fetal growth restriction, oligohydramnios and premature rupture of fetal membrane were observed. There was no significant difference between the two groups in the incidence of abortion and premature delivery before pregnancy. The incidence of abortion and premature delivery was significantly higher in the group of 10 mg / day hormone dosage than in the group of 鈮，

本文編號：1922469