本文選題：宮頸癌 + 放射治療　； 參考：《山東醫(yī)藥》2015年27期

【摘要】：目的觀察圖像引導(dǎo)自適應(yīng)放療(IGART)在宮頸癌治療中的應(yīng)用效果。方法接受放療的宮頸癌患者14例,借助4D CT掃描圖像設(shè)計(jì)放療計(jì)劃及劑量,放療過程中采用錐形束CT(CBCT)掃描,獲取用于IGART的圖像。放療前采用CBCT進(jìn)行位置驗(yàn)證掃描,并將獲取的CBCT圖像與計(jì)劃CT圖像進(jìn)行3D-3D配準(zhǔn),測量患者的擺位誤差。借助CBCT圖像勾畫放療過程中的腫瘤靶區(qū)(PTV),評價計(jì)劃靶區(qū)(PTV)對GTV的覆蓋情況。結(jié)果 14例患者共執(zhí)行131次CT掃描,其中治療前掃描95次,在線匹配后驗(yàn)證掃描36次。在治療前95次掃描中,患者頭腳、前后和左右方向的擺位誤差分別為(0.38±0.07)、(0.30±0.09)、(0.28±0.10)cm。36次驗(yàn)證掃描后,患者頭腳、前后和左右方向的擺位誤差均減少(P均0.05)�；颊叻执畏暖熎陂g,CBCT圖像與計(jì)劃CT圖像匹配修正前GTV溢出PTV 6次,未覆蓋率為6.3%(6/95),匹配修正后分別為2次和2.1%。結(jié)論 IGART用于宮頸癌治療可減少并修正患者的擺位誤差,降低腫瘤靶區(qū)脫靶的發(fā)生率,縮小臨床靶區(qū)的外擴(kuò)邊界。
[Abstract]:Objective to observe the effect of image-guided adaptive radiotherapy (IGART) in the treatment of cervical cancer. Methods Fourteen patients with cervical cancer received radiotherapy were treated with 4D CT scan. The radiation plan and dose were designed by 4D CT scan. The IGART images were obtained by cone-beam CTB CT scanning during radiotherapy. CBCT was used for position verification scanning before radiotherapy and 3D-3D registration was performed between the acquired CBCT images and the planned CT images to measure the positioning errors of the patients. CBCT images were used to describe the GTV coverage of tumor targets during radiotherapy. Results A total of 131 CT scans were performed in 14 patients, of which 95 were scanned before treatment and 36 were verified after online matching. In 95 scans before treatment, the errors of head and foot, front and right, and left and right directions were 0. 38 鹵0. 07 and 0. 28 鹵0. 28 鹵0. 28 鹵0.10)cm.36, respectively, and the errors of head and foot, front and right, left and right directions were all decreased by 0. 05% (P < 0. 05) after 0. 28 鹵0. 28 鹵0. 28 鹵0. 28 鹵0. 28 鹵0. 28 鹵0. 28 鹵0. 28%. There were 6 times of GTV spillover PTV before matching with planned CT images, 6 times without coverage and 2 times and 2.1 times after matching and correction, respectively. Conclusion IGART for cervical cancer treatment can reduce and correct the positioning error, reduce the incidence of tumor target miss, and reduce the expanding boundary of clinical target area.
【作者單位】： 汕頭大學(xué)醫(yī)學(xué)院附屬腫瘤醫(yī)院;
【分類號】：R737.33

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本文編號：1915128