本文選題：動(dòng)態(tài)增強(qiáng)磁共振成像 + 高強(qiáng)度聚焦超聲消融�。� 參考：《重慶醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的探討動(dòng)態(tài)增強(qiáng)MRI(DCE-MRI)定量參數(shù)與高強(qiáng)度聚焦超聲(high-intensity focused ultrasound,HIFU)子宮肌瘤消融術(shù)療效的相關(guān)性。方法HIFU術(shù)前對(duì)65例子宮肌瘤患者(82個(gè)子宮肌瘤)行DCE-MRI檢查,經(jīng)后處理軟件獲得子宮肌瘤定量參數(shù)Ktrans、Ve、Kep、Vp值以及子宮肌層定量參數(shù)Ktrans值,分析子宮肌瘤術(shù)前定量參數(shù)與其HIFU術(shù)后消融率的相關(guān)性。將子宮肌瘤按其Ktrans值高于(或低)相應(yīng)子宮肌層分為高Ktrans肌瘤及低Ktrans肌瘤,比較兩組肌瘤Ktrans以及消融率的差異。結(jié)果肌瘤消融率與肌瘤Ktrans值呈負(fù)相關(guān)(r=㧟0.411),具有統(tǒng)計(jì)學(xué)意義(P0.01)。肌瘤消融率與肌瘤Ve、Kep、Vp值的相關(guān)性無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。高Ktrans肌瘤與低Ktrans肌瘤間消融率及Ktrans值差異具有統(tǒng)計(jì)學(xué)意義(P均0.01),前者Ktrans值較后者高,而消融率較后者低。結(jié)論子宮肌瘤Ktrans值越高,其HIFU消融效果越差。對(duì)照相應(yīng)子宮肌層Ktrans值能夠初步判斷子宮肌瘤的消融效果。DCE-MRI可為子宮肌瘤HUFI消融術(shù)選擇患者提供依據(jù)。
[Abstract]:Objective to investigate the correlation between dynamic enhanced focused DCE-MRI quantitative parameters and the effect of high-intensity focused ultrasound (HIFU) hysteromyoma ablation. Methods Sixty-five patients with uterine leiomyoma (82 uterine leiomyomas) were examined by DCE-MRI before HIFU. The quantitative parameters of uterine leiomyoma were obtained by post-processing software, including KTrans-Veg KepVp and Ktrans of uterine myometrium. To analyze the correlation between preoperative quantitative parameters of uterine leiomyoma and ablation rate after HIFU. Uterine leiomyoma was divided into high Ktrans myoma and low Ktrans myoma according to its Ktrans value higher (or lower). The difference of Ktrans and ablation rate between the two groups was compared. Results there was a negative correlation between the ablation rate and the Ktrans value of leiomyoma (P 0.01). There was no significant correlation between the ablation rate of leiomyoma and the value of V _ p in leiomyoma (P 0.05). There were significant differences in ablation rate and Ktrans value between high Ktrans myoma and low Ktrans myoma (P < 0.01). The Ktrans value of the former was higher than that of the latter, and the ablation rate was lower than that of the latter. Conclusion the higher the Ktrans value of uterine leiomyoma, the worse the effect of HIFU ablation. Compared with the corresponding myometrium Ktrans value, DCE-MRI can preliminarily judge the ablation effect of uterine leiomyoma. DCE-MRI can provide evidence for the choice of uterine myoma HUFI ablation.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R737.33;R445.2

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