本文選題：甲氨蝶呤 + 給藥方案　； 參考：《中國(guó)臨床藥理學(xué)雜志》2015年05期

【摘要】：目的分析甲氨蝶呤(MTX)治療異位妊娠(EP)的臨床療效,并建立其特征指標(biāo)治療前血清人絨毛膜促性腺激素(h CG)的臨界值。方法入選2010年4月至2012年3月福建省婦幼保健院用MTX治療的異位妊娠患者150例為研究對(duì)象,分為2組。試驗(yàn)組(n=78)用1 mg·kg-1MTX分3次間隔48 h肌內(nèi)注射;對(duì)照組(n=72)用1 mg·kg-1MTX,單次肌內(nèi)注射;2組均根據(jù)血清h CG下降幅度,必要時(shí)可再給MTX。比較MTX不同給藥方案的臨床療效及不良反應(yīng)發(fā)生率,并分析血清h CG等因素對(duì)MTX近期療效的影響。結(jié)果 2組的臨床療效比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。試驗(yàn)組不良反應(yīng)發(fā)生率低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。試驗(yàn)組治療前血清h CG最佳工作點(diǎn)為1495.49 m IU·m L-1。結(jié)論 MTX多次給藥方案的臨床療效與單劑方案相當(dāng),但不良反應(yīng)發(fā)生率較低;治療前血清h CG≤1500 m IU·m L-1可選用該方案。
[Abstract]:Objective to analyze the clinical efficacy of methotrexate (MTX) in the treatment of ectopic pregnancy (EPV) and to establish the critical value of serum human chorionic gonadotropin (hCG) before treatment. Methods from April 2010 to March 2012, 150 patients with ectopic pregnancy treated with MTX in Fujian Maternal and Child Health Care Hospital were selected as study subjects, and divided into two groups. In the test group, 1 mg kg-1MTX was injected intramuscularly at intervals of 48 h, while the control group was given 1 mg kg-1 MTX. The two groups were treated with a single intramuscular injection of 1 mg kg-1 MTX. To compare the clinical efficacy and adverse reaction rate of different MTX regimen, and to analyze the influence of serum hCG and other factors on the short-term efficacy of MTX. Results there was no significant difference in clinical efficacy between the two groups (P 0.05). The incidence of adverse reactions in the test group was lower than that in the control group, and the difference was statistically significant (P 0.05). The optimal working point of serum hCG before treatment was 1495.49 m IU m L -1 in the experimental group. Conclusion the clinical efficacy of MTX regimen is similar to that of single dose regimen, but the incidence of adverse reactions is low, and the serum hCG 鈮，

本文編號(hào)：1895789