本文選題：人乳頭瘤狀病毒(HPV) + HPV基因分型��； 參考：《中國婦產(chǎn)科臨床雜志》2015年05期

【摘要】：目的探討江蘇地區(qū)女性宮頸疾病HPV基因檢測的感染情況及流行分布。方法用Luminex200流式熒光雜交技術(shù)對來自江蘇省13個地區(qū)的500多家醫(yī)院門診就診的6 003例患者進行了HPV基因分型檢測,研究HPV在女性人群中的感染率,基因型別和地區(qū)分布的特點。結(jié)果 6 003例標本中HPV陽性例數(shù)1 842例,總感染率為30.68%,蘇北、蘇中、蘇南感染率差異無統(tǒng)計學意義(P0.05);HPV單一亞型感染率為65.48%,高于多重亞型感染的情況,差異有統(tǒng)計學意義(P0.05);HPV高危亞型感染最多的亞型是16、52、58、53型;蘇北地區(qū)50歲以上人群的陽性率高于其他年齡層,差異有統(tǒng)計學意義(P0.05);蘇中地區(qū)與蘇北地區(qū),各年齡層人群的HPV感染率差異均無統(tǒng)計學意義(P0.05)。結(jié)論江蘇地區(qū)HPV感染率在中國大陸地區(qū)屬于較高狀態(tài),多重亞型感染的比例也相對較高,HPV感染最多的亞型中16和58屬于高危型HPV病毒中致癌活性最高的亞型之一。這些信息也都提示江蘇地區(qū)宮頸癌的防治工作頗為嚴峻。同時,在江蘇地區(qū)年齡17~35歲和大于50歲都屬于HPV感染的高峰年齡,尤其是蘇北地區(qū)年齡大于50歲人群。加強對這些人群的宮頸病變的檢查對于宮頸癌的早期診斷和治療有積極的意義。
[Abstract]:Objective to investigate the prevalence and prevalence of HPV gene detection in women with cervical diseases in Jiangsu province. Methods HPV genotyping was performed in 6 003 outpatients from more than 500 hospitals in 13 regions of Jiangsu Province by Luminex200 flow fluorescence hybridization. The infection rate, genotypic and regional distribution of HPV in female population were studied. Results among 6 003 specimens, 1 842 cases were positive for HPV, the total infection rate was 30.68. There was no significant difference in infection rate between north Jiangsu, middle Jiangsu and southern Jiangsu. The infection rate of single subtype of HPV was 65.48, which was higher than that of multiple subtype infection. The most high risk subtypes of P0.05HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-@@ There was no significant difference in HPV infection rate among different age groups (P 0.05). Conclusion the infection rate of HPV in Jiangsu is high in mainland China, and 16 and 58 of the most frequent subtypes of HPV infection belong to one of the most carcinogenic subtypes of high risk HPV virus. These information also suggest that the prevention and treatment of cervical cancer in Jiangsu is rather severe. At the same time, the age of 1735 years old and over 50 years old belong to the peak age of HPV infection in Jiangsu area, especially in north Jiangsu area. Strengthening the detection of cervical lesions in these populations has positive significance for early diagnosis and treatment of cervical cancer.
【作者單位】： 江蘇省南京金域醫(yī)學檢驗所;
【分類號】：R737.33

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