本文選題：子癇前期 + 血清胎盤生長因子��； 參考：《中山大學(xué)學(xué)報(醫(yī)學(xué)科學(xué)版)》2015年06期

【摘要】：【目的】探討血清胎盤生長因子(PIGF)、可溶性血管內(nèi)皮生長因子受體-1(s VEGFR-1)、一氧化氮(NO)濃度聯(lián)合子宮動脈搏動指數(shù)(PI)在高危孕婦中預(yù)測子癇前期發(fā)生的價值。【方法】收集162例具有子癇前期高危因素孕婦妊娠22~26周時的血清標本,應(yīng)用酶聯(lián)免疫吸附試驗(ELISA)檢測PIGF及s VEGFR-1濃度,比色法檢測NO濃度,同期行子宮動脈多普勒超聲檢查測定PI值。【結(jié)果】134例孕婦發(fā)生子癇前期(子癇前期組),128例孕婦血壓始終維持正常(血壓正常組)。2子癇前期組孕婦血清中PIGF、s VEGFR-1、NO水平及PI分別為(264±116)pg/m L、(4823±1562)pg/m L、(57±28)μmol/L、2.7±0.1;血壓正常組分別為(418±130)pg/m L、(1102±158)pg/m L、(107±28)μmol/L、2.2±0.2。兩組比較,差異均有統(tǒng)計學(xué)意義(P0.001)。3單一參數(shù)預(yù)測子癇前期的敏感度和特異度Pl GF為78.0%和80.7%(切割值為286.3 pg/m L時),s VEGFR-1為81.2%和83.5%(切割值為2 005.0 pg/m L時),NO為75.2%和80.0%(切割值為50.9μmol/L時),PI為79.6%和86.2%(切割值為2.31時)。聯(lián)合4項參數(shù)陽性值預(yù)測子癇前期的敏感度和特異度為92.7%和95.6%,均高于單一參數(shù)(P0.001)。血清PIGF、s VEGFR-1、NO的濃度與母親的妊娠結(jié)局顯著關(guān)聯(lián)(P0.001)�！窘Y(jié)論】血清PIGF、s VEGFR-1、NO濃度聯(lián)合PI在孕22~26周的高危孕婦中預(yù)測子癇前期的發(fā)生有較好的臨床價值。
[Abstract]:[objective] to study the value of serum placental growth factor (PIGFN), soluble vascular endothelial growth factor receptor (VEGFR-1), nitric oxide (no) and uterine artery pulsatile index (Pi) in predicting preeclampsia in high-risk pregnant women. The serum samples of 162 pregnant women with high risk factors of preeclampsia at 2226 weeks of pregnancy were collected. Enzyme linked immunosorbent assay (Elisa) was used to detect the concentration of PIGF and s VEGFR-1, and the concentration of no was detected by colorimetry. [results] 134 pregnant women developed preeclampsia (128 pregnant women in preeclampsia group) and their blood pressure remained normal (PIGFs VEGFR-1no in serum of preeclampsia group of normal blood pressure group. 2. 2 preeclampsia group) The levels of Pi and Pi were 484 鹵116)pg/m / L 4823 鹵1562)pg/m / L = 57 鹵28 渭 mol / L / L = 2.7 鹵0.1, respectively, and those of normal blood pressure group were 1 102 鹵158)pg/m / L ~ (107 鹵28) 渭 mol / L ~ (2. 2 鹵0. 2) 渭 mol / L ~ (2) 鹵0. 2, respectively. The two groups were compared, There were significant differences in the sensitivity and specificity of P0.001n.3 single parameter in predicting preeclampsia. The sensitivity and specificity of Pl GF were 78.0% and 80.7% (when the cutting value was 286.3 pg/m / L, the VEGFR-1 was 81.2% and 83.5% respectively) (when the cutting value was 2 005.0 pg/m / L, the no was 75.2% and 80.0% (the cutting value was 50.9 渭 mol/L). 79.6% and 86.2% (cutting value 2.31%). The sensitivity and specificity in predicting preeclampsia with positive values of 4 parameters were 92.7% and 95.6%, respectively, which were higher than those of single parameter (P 0.001). There was a significant correlation between the concentration of serum PIGFFN VEGFR-1no and the pregnancy outcome of the mother. [conclusion] Serum PIGFFs VEGFR-1no concentration combined with Pi has a good clinical value in predicting preeclampsia in high risk pregnant women at 2226 weeks of gestation.
【作者單位】： 中山大學(xué)附屬第三醫(yī)院產(chǎn)科;
【基金】：廣東省科技廳社會發(fā)展項目(2011B031800)
【分類號】：R714.244

【參考文獻】

相關(guān)期刊論文 前1條

1 沈紅玲;陳漢平;;胎盤生長因子與子癇前期發(fā)病及一氧化氮關(guān)系的研究[J];現(xiàn)代婦產(chǎn)科進展;2006年02期

【二級參考文獻】

相關(guān)期刊論文 前2條

1 沈紅玲,陳漢平;胎盤生長因子及其受體的分子特性的研究進展[J];國外醫(yī)學(xué).婦幼保健分冊;2004年05期

2 程國梅,石一復(fù),陳曉端;血紅素氧合酶在正常妊娠絨毛和胎盤組織中的表達及定位[J];中華婦產(chǎn)科雜志;2003年09期

【相似文獻】

相關(guān)期刊論文 前4條

1 余海浪;馬文麗;周玨宇;鄭文嶺;;乳腺癌組織PIGF表達及其臨床意義的探討[J];中華腫瘤防治雜志;2010年08期

2 高愛紅;田偉;;冠心病患者介入治療前后PIGF和CRP的變化及臨床意義[J];中國醫(yī)藥導(dǎo)刊;2011年11期

3 李勇;王巧芝;鄭群;張穎軒;張俊嶺;李擁軍;;不同劑量阿托伐他汀對急性心肌梗死患者擇期行PCI后PIGF及心肌灌注的影響[J];山東醫(yī)藥;2012年45期

4 ;[J];;年期

相關(guān)碩士學(xué)位論文 前3條

1 Gyanendra Swar（甘寧）;PIGF在無淋巴結(jié)轉(zhuǎn)移胃癌中的表達以及與微血管密度的關(guān)系[D];山東大學(xué);2011年

2 許金花;HIF-1α，，VEGF及PIGF在不同海拔世居藏族及移居漢族的水平及意義的研究[D];青海大學(xué);2012年

3 許金花;HIF-1α、VEGF及PIGF在不同海拔世居藏族及移居漢族的水平及意義的研究[D];青海大學(xué);2012年

本文編號：1869335