發(fā)布時(shí)間：2018-05-10 11:08

  本文選題：高危型人乳頭瘤病毒 + 自然清除�。� 參考：《中國(guó)醫(yī)學(xué)科學(xué)院學(xué)報(bào)》2015年05期

【摘要】：目的了解西安地區(qū)女性生殖道高危型人乳頭瘤病毒(HR-HPV)感染自然轉(zhuǎn)歸規(guī)律及影響因素。方法采用HPV-DNA分型檢測(cè)技術(shù)對(duì)760例初次感染HR-HPV的西安地區(qū)女性進(jìn)行隨訪檢測(cè),必要時(shí)行液基細(xì)胞學(xué)和/或陰道鏡檢查。結(jié)果 760名女性生殖道HR-HPV自然清除率為71.58%,中位時(shí)間8.10個(gè)月;持續(xù)感染率為22.63%,中位時(shí)間17.23個(gè)月;進(jìn)展率為5.79%,中位時(shí)間29.34個(gè)月。50歲以上年齡組自然清除率(P=0.000)、持續(xù)感染率(P=0.000)和進(jìn)展率(P=0.040)與其他年齡組相比差異有統(tǒng)計(jì)學(xué)意義。多重感染組持續(xù)感染率明顯低于單一感染組(P=0.010),但其中位時(shí)間明顯長(zhǎng)于單一感染組(P=0.018)。易進(jìn)展型別為HPV-16、HPV-33、HPV-58、HPV-18、HPV-52、HPV-68,其中HPV-16在宮頸上皮內(nèi)瘤變(CIN)Ⅲ/宮頸癌(CC)中最常見,占85.00%。結(jié)論多數(shù)HR-HPV感染在2年內(nèi)被清除,僅少數(shù)進(jìn)展為CIN/CC。50歲以上女性自然清除率低,持續(xù)感染率和進(jìn)展率高,多重感染影響病毒持續(xù),HPV-16是本地區(qū)最常見的致癌株。
[Abstract]:Objective to investigate the natural outcome and influencing factors of high risk human papillomavirus (HR-HPVV) infection in female genital tract in Xi'an. Methods HPV-DNA typing technique was used to detect 760 women in Xi'an area who were first infected with HR-HPV, and liquid-based cytology and / or colposcopy were performed when necessary. Results the natural clearance rate of HR-HPV in 760 female genital tract was 71.58, the median time was 8.10 months, the persistent infection rate was 22.633.The median time was 17.23 months. The rate of progression was 5.79, the median time was 29.34 months. The natural clearance rate was 0.000, the rate of persistent infection was 0.000) and the rate of progression was 0.040), which was significantly different from that of other age groups. The persistent infection rate in the multiple infection group was significantly lower than that in the single infection group, but the site time was significantly longer than that in the single infection group. The easily progressive type was HPV-16, HPV-33, HPV-58, HPV-18, HPV-52, HPV-68, in which HPV-16 was the most common type in cervical intraepithelial neoplasia (cin 鈪，

本文編號(hào)：1869056