本文選題：多囊卵巢綜合征(PCOS) + 不孕癥��； 參考：《新中醫(yī)》2016年01期

【摘要】：目的:觀察在常規(guī)西藥治療基礎(chǔ)上,采用丹溪治濕痰方聯(lián)合黃連素治療多囊卵巢綜合征(PCOS)不孕癥痰濕阻滯證的療效以及對血清瘦素(LP)和游離脂肪酸(FFA)水平的影響。方法:選取本院收治的116例PCOS不孕癥患者,按隨機數(shù)字表法分為治療組和對照組各58例。所有患者給予炔雌醇環(huán)丙孕酮片和克羅米芬促排卵治療,治療組加用丹溪治濕痰方和黃連素片治療。2組療程均為4個月經(jīng)周期。記錄2組患者在6個月經(jīng)周期內(nèi)的臨床妊娠率;比較2組的卵巢體積和子宮體部子宮內(nèi)膜厚度,檢測血清LP和FFA水平。結(jié)果:總?cè)焉锫手委熃M為62.07%,對照組為32.76%,2組比較,差異有統(tǒng)計學(xué)意義(P0.01)。治療后,2組卵巢體積均減小(P0.01),子宮內(nèi)膜厚度均增加(P0.01);治療組卵巢體積小于對照組,子宮內(nèi)膜厚度值大于對照組,差異均有統(tǒng)計學(xué)意義(P0.01)。治療后,2組血清LP和FFA水平均較治療前下降(P0.01);治療組血清LP和FFA水平均低于對照組,差異均有統(tǒng)計學(xué)意義(P0.01)。結(jié)論:在常規(guī)西藥治療基礎(chǔ)上,采用丹溪治濕痰方聯(lián)合黃連素治療PCOS不孕癥痰濕阻滯證患者療效顯著,可縮小卵巢體積,同時增加子宮內(nèi)膜厚度,提高臨床妊娠率;降低患者血清LP和FFA水平可能是該療法發(fā)揮上述療效的機制之一。
[Abstract]:Objective: to observe the therapeutic effect of Danxi Zhishitan recipe combined with berberine on phlegm dampness block syndrome in infertility with polycystic ovary syndrome (PCOS) and the effect on serum leptin (LP) and free fatty acid (FFA) levels. Methods: 116 patients with PCOS infertility were randomly divided into treatment group (n = 58) and control group (n = 58). All patients were treated with ethylestradiol cycloprogestrel and clomiphene to promote ovulation. The treatment group was treated with Danxi Zhishitan recipe and berberine tablet for 4 menstrual cycles. The clinical pregnancy rates of the two groups were recorded during 6 menstrual cycles, the ovarian volume and endometrial thickness of the uterus were compared, and the serum LP and FFA levels were measured. Results: the total pregnancy rate was 62.07 in the treatment group and 32.76 in the control group. The difference was statistically significant (P 0.01). After treatment, the ovarian volume decreased and the endometrial thickness increased in both groups, and the ovarian volume in the treatment group was smaller than that in the control group, and the endometrial thickness value was higher than that in the control group (P 0.01). After treatment, the serum LP and FFA levels in the two groups were lower than those before treatment, and the levels of LP and FFA in the treatment group were lower than those in the control group (P 0.01). Conclusion: on the basis of routine western medicine treatment, Danxi Zhishitan prescription combined with berberine is effective in treating PCOS infertility with phlegm dampness block, which can reduce the volume of ovary, increase the thickness of endometrium and increase the clinical pregnancy rate. The reduction of serum LP and FFA levels may be one of the mechanisms of this therapy.
【作者單位】： 溫州醫(yī)科大學(xué);浙江中醫(yī)藥大學(xué)附屬溫州中西醫(yī)結(jié)合醫(yī)院婦產(chǎn)科;
【分類號】：R711.75

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