本文選題：子宮內膜腺癌 + Gankyrin��； 參考：《中南大學》2014年博士論文

【摘要】：目的：研究Gankyrin蛋白和β-catenin蛋白在子宮內膜腺癌中的表達,以探討兩種蛋白在子宮內膜腺癌發(fā)生發(fā)展中的作用。 方法：應用免疫組織化學技術檢測46例子宮內膜腺癌與l0例正常子宮內膜中Gankyrin蛋白和β-catenin蛋白的表達。探討其與年齡、癌組織肌層浸潤深度、淋巴結轉移、病理分級及FIGO分期的關系。分析二者在子宮內膜腺癌組中的相關性。 結果： 1. Gankyrin蛋白和β-catenin蛋白在子宮內膜腺癌組中的表達均主要定位在腺上皮的細胞核與細胞質中,在子宮內膜腺癌組中,Gankyrin蛋白和β-catenin蛋白陽性表達率分別為67.39%和78.26%,均分別高于其在正常子宮內膜組中的40.00%和30.00%(P0.05)。 2. Gankyrin蛋白在子宮內膜腺癌組中的表達與年齡、癌組織肌層浸潤深度、淋巴結轉移、病理分級及FIGO分期均無相關性(P0.05)。 3. β-catenin蛋白在子宮內膜腺癌組中的表達隨著病理分級、FIGO分期的升高以及淋巴結的轉移而增強(P0.05),而與年齡及癌組織肌層浸潤深度無關(P0.05)。 4. Gankyrin蛋白與β-catenin蛋白在子宮內膜腺癌組中的表達呈正相關(P0.05)。 結論： 1. Gankyrin蛋白及β-catenin蛋白在子宮內膜腺癌中的表達均高于其在正常子宮內膜中的表達,提示兩者均可能與子宮內膜腺癌的發(fā)病有關。 2. β-catenin蛋白的表達隨著子宮內膜腺癌病理分級、FIGO分期的升高以及淋巴結的轉移而增強,可望作為判斷病情嚴重程度及預后的指標之一。
[Abstract]:Aim: to investigate the expression of Gankyrin protein and 尾 -catenin protein in endometrial adenocarcinoma. Methods: the expression of Gankyrin protein and 尾 -catenin protein in 46 cases of endometrial adenocarcinoma and 10 cases of normal endometrium were detected by immunohistochemistry. To investigate the relationship between age, depth of myometrial invasion, lymph node metastasis, pathological grade and FIGO stage. To analyze the correlation between them in endometrial adenocarcinoma group. Results: 1. The expression of Gankyrin protein and 尾 -catenin protein in endometrial adenocarcinoma was mainly located in the nucleus and cytoplasm of glandular epithelium. The positive rates of Gankyrin protein and 尾 -catenin protein in endometrial adenocarcinoma group were 67.39% and 78.26%, respectively, which were higher than those in normal endometrium group (40.00%) and 30.00-catenin protein (30.005%). 2. There was no correlation between the expression of Gankyrin protein and age, depth of myometrial invasion, lymph node metastasis, pathological grade and FIGO stage in endometrial adenocarcinoma group (P 0.05). 3. The expression of 尾 -catenin protein in endometrial adenocarcinoma increased with the increase of Figo stage and lymph node metastasis, but had no relationship with age and depth of myometrium invasion. 4. There was a positive correlation between the expression of Gankyrin protein and 尾 -catenin protein in endometrial adenocarcinoma group (P 0.05). Conclusion: 1. The expression of Gankyrin protein and 尾 -catenin protein in endometrial adenocarcinoma was higher than that in normal endometrium, suggesting that both of them may be related to the pathogenesis of endometrial adenocarcinoma. 2. The expression of 尾 -catenin protein is increased with the increase of pathological grade and Figo stage of endometrial adenocarcinoma and lymph node metastasis. It is expected to be one of the indexes to judge the severity and prognosis of endometrial adenocarcinoma.
【學位授予單位】：中南大學
【學位級別】：博士
【學位授予年份】：2014
【分類號】：R737.33

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