本文選題：多囊卵巢綜合征 + 促甲狀腺激素��； 參考：《山東大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年01期

【摘要】：目的分析多囊卵巢綜合征(PCOS)患者的促甲狀腺激素(TSH)對血糖、血脂的影響。方法選擇無甲狀腺疾病治療史的PCOS患者1 034例,測量其身高、體質(zhì)量、腰圍、臀圍、血壓等,實(shí)驗(yàn)室檢測包括TSH、性激素、血糖、胰島素、血脂總膽固醇(TC)、三酰甘油TG)、低密度脂蛋白膽固醇(LDL-C)等指標(biāo),計(jì)算體質(zhì)量指數(shù)(BMI)、腰臀比,穩(wěn)態(tài)模型評估胰島素抵抗指數(shù)(HOMA-IR)。并根據(jù)TSH界值將PCOS患者分為TSH正常組(0.27μIU/m L≤TSH≤4.2μIU/m L)和TSH升高組(TSH4.2μIU/m L),比較兩組間各項(xiàng)生化指標(biāo)的差異。結(jié)果 1 034例PCOS患者中有163例(15.76%)TSH升高。TSH升高組和TSH正常組的患者比較體質(zhì)量(P=0.015)、BM I(P=0.021)、臀圍(P=0.023)、收縮壓(P=0.006)、舒張壓(P=0.001),差異有統(tǒng)計(jì)學(xué)意義,且TSH升高組的肥胖患者占比明顯高于TSH正常組。兩組間的2 h血糖、空腹胰島素、2 h胰島素以及HOMA-IR差異均無統(tǒng)計(jì)學(xué)意義(P0.05),但PCOS伴TSH升高組相比TSH正常組有升高趨勢。TSH升高組PCOS患者TC(P=0.027)、TG(P=0.022)及LDL-C(P=0.049)高于TSH正常組。相關(guān)性分析結(jié)果顯示,TSH與臀圍、收縮壓、舒張壓、空腹胰島素、2 h胰島素、HOMA-IR、TC、TG、LDL-C呈正相關(guān)性(P均0.05)。結(jié)論 TSH升高的PCOS患者更容易發(fā)生肥胖,導(dǎo)致血脂代謝紊亂,同時(shí)糖代謝異常和胰島素抵抗有加劇的趨勢,建議PCOS患者常規(guī)檢查TSH。
[Abstract]:Objective to analyze the effect of TSHs on blood glucose and blood lipid in patients with polycystic ovary syndrome (PCOS). Methods 1 034 PCOS patients with no history of thyroid disease were selected and their height, body mass, waist circumference, hip circumference, blood pressure were measured. The body mass index (BMI), waist-to-hip ratio (WHR), insulin resistance index (HOMA-IRI) and insulin resistance index (HOMA-IRI) were calculated. The patients with PCOS were divided into normal TSH group (0.27 渭 IU/m L 鈮，

本文編號：1777932