本文選題：支原體感染 + 不孕　； 參考：《中國中西醫(yī)結(jié)合雜志》2017年12期

【摘要】：目的觀察消支助孕湯聯(lián)合重組人干擾素α-2a栓陰道外用治療支原體感染性不孕的臨床療效。方法選取支原體陽性不孕患者226例,隨機(jī)分為治療組和對照組,治療組應(yīng)用消支助孕湯口服聯(lián)合重組人干擾素α-2a栓陰道外用;對照組應(yīng)用多西環(huán)素口服加重組人干擾素α-2a栓陰道外用。觀察兩組解脲支原體(Uu)轉(zhuǎn)陰率,治療前后抗精子抗體(AsAb)、抗子宮內(nèi)膜抗體(AEMAb)變化,妊娠率及不良反應(yīng)情況。結(jié)果治療組妊娠率67.8%(80/118),明顯優(yōu)于對照組[37.9%(41/108)],差異有統(tǒng)計(jì)學(xué)意義(χ2=20.18,P0.01);治療組Uu轉(zhuǎn)陰率為92.4%(109/118)、流產(chǎn)率2.5%(2/80),對照組Uu轉(zhuǎn)陰率93.5%(101/108)、流產(chǎn)率7.3%(3/41),兩組比較,Uu轉(zhuǎn)陰率及流產(chǎn)率差異均無統(tǒng)計(jì)學(xué)意義(P0.05);治療后兩組AsAb和AEMAb陽性率較治療前均下降(P0.05),且治療組陽性率明顯低于對照組(P0.05),治療組轉(zhuǎn)陰率優(yōu)于對照組(P0.05);治療后抗體陰性者妊娠率78.5%(106/135),明顯優(yōu)于抗體陽性者[16.5%(15/91)],差異有統(tǒng)計(jì)學(xué)意義(χ~2=84.10,P0.01);抗體陰性者流產(chǎn)率1.9%(2/106),低于抗體陽性者[20.0%(3/15)],差異有統(tǒng)計(jì)學(xué)意義(χ~2=10.88,P0.05)。結(jié)論消支助孕湯口服聯(lián)合重組人干擾素α-2a栓陰道外用治療支原體感染不孕患者,能有效清除Uu,降低自身免疫激活狀態(tài),從而提高了妊娠率,降低了流產(chǎn)率。
[Abstract]:Objective to observe the clinical effect of Xiaoyingren decoction (XYT) combined with recombinant human interferon 偽-2a suppository for the treatment of mycoplasma infective infertility. Methods 226 cases of mycoplasma positive infertility were randomly divided into treatment group and control group. The treatment group was treated with Xiaoyinghentang orally combined with recombinant human interferon 偽 -2a suppository for external vaginal use. The control group was treated with doxycycline orally and recombinant human interferon 偽-2a suppository for vaginal use. The negative rate of Ureaplasma Urealyticum Ureaplasma Urealyticum (UU), the changes of anti-sperm antibody, anti-endometrial antibody, pregnancy rate and adverse reaction were observed before and after treatment. After treatment, the positive rates of AsAb and AEMAb in both groups were lower than those before treatment, and the positive rate of AsAb and AEMAb in the treatment group was significantly lower than that in the control group (P 0.05), the negative conversion rate in the treatment group was better than that in the control group (P 0.05), and the pregnancy rate in the patients with negative antibody after treatment was 78.5 / 135, which was significantly better than that in the antibody positive group. [16.5% 15 / 91], the difference was statistically significant (蠂 2 + 84.10% P 0.01); the abortion rate of those with negative antibody was 1.9% 10 / 106, lower than that of those with positive antibody [20.0% / 15], and the difference was statistically significant (蠂 2 10.8 8 P 0.05). Conclusion the oral administration of Xiaoyinghentang combined with recombinant human interferon 偽 -2a suppository for vaginal treatment of infertile patients with mycoplasma infection can effectively remove UU and decrease the state of autoimmune activation, thus increasing the pregnancy rate and reducing the abortion rate.
【作者單位】： 河北省衡水市第四人民醫(yī)院婦科;
【分類號】：R711.6

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