孕前、孕早期家用化學(xué)品使用情況的影響因素及其與妊娠結(jié)局關(guān)聯(lián)的隊(duì)列研究
發(fā)布時(shí)間:2018-04-18 12:40
本文選題:孕婦 + 妊娠結(jié)局; 參考:《安徽醫(yī)科大學(xué)》2014年碩士論文
【摘要】:目的 描述孕婦孕前、孕早期家用化學(xué)品的使用情況,分析孕婦孕前、孕早期家用化學(xué)品使用情況的影響因素,進(jìn)一步探討孕前、孕早期家用化學(xué)品使用與早產(chǎn)、低出生體重、小于胎齡兒以及胎兒宮內(nèi)生長發(fā)育指標(biāo)的關(guān)聯(lián)。 方法 自2008年10月至2010年10月,征募了在安徽省合肥、蕪湖、馬鞍山市的婦幼保健機(jī)構(gòu)進(jìn)行初次孕產(chǎn)期保健體檢,建立保健手冊(cè),并且分娩記錄完整的孕婦。在隨訪期間,選用本教研室編制的《孕產(chǎn)期母嬰健康記錄表》采集了孕婦的人口學(xué)資料、本次妊娠相關(guān)情況、不良生活方式、孕前及孕早期家用化學(xué)品使用情況、妊娠期心理應(yīng)激狀況等資料;收集新生兒娩出時(shí)的出生體重、身長、頭圍、胸圍、孕周、性別等信息,所有參加該研究的孕婦都簽署了知情同意書。采用Wilcoxon秩和檢驗(yàn)、Kruskal-Wallis秩和檢驗(yàn)、Pearson2檢驗(yàn)比較孕婦孕前、孕早期家用化學(xué)品使用情況在不同人口統(tǒng)計(jì)學(xué)特征、妊娠相關(guān)情況、不良生活方式、妊娠期心理應(yīng)激情況之間的分布差異;運(yùn)用線性回歸模型分析孕前、孕早期家用化學(xué)品使用與胎兒宮內(nèi)生長發(fā)育指標(biāo)的關(guān)聯(lián);采用Logistic回歸模型分析孕前、孕早期家用化學(xué)品使用情況的影響因素,并且探討孕前、孕早期家用化學(xué)品使用與早產(chǎn)、低出生體重、小于胎齡兒三類不良妊娠結(jié)局的關(guān)聯(lián)。 結(jié)果 孕前家用化學(xué)品資料完整進(jìn)入分析的孕婦共計(jì)10241人,美白霜的使用率最高(59.2%),其他家用化學(xué)品的使用率相對(duì)較低(≤35%),Logistic回歸分析顯示合肥、馬鞍山市的家用化學(xué)品使用率低于蕪湖市,孕婦的文化程度與孕前家用化學(xué)品使用較多顯著相關(guān),而孕婦低齡、孕前較低的體質(zhì)指數(shù)(body mass index,BMI)、有流產(chǎn)史、有婦科感染史、孕期抑郁、焦慮、孕前半年服用過避孕藥、有吸煙史、飲酒史、服用/注射過藥物是孕前家用化學(xué)品使用較多的正向關(guān)聯(lián)因素。Logistic回歸結(jié)果顯示,孕前家用化學(xué)品使用與早產(chǎn)無統(tǒng)計(jì)學(xué)顯著關(guān)聯(lián)(中分組對(duì)低分組:RR=0.82,95%CI=0.59~1.14;高分組對(duì)低分組:RR=0.80,95%CI=0.63~1.01),與低出生體重亦無統(tǒng)計(jì)學(xué)顯著關(guān)聯(lián)(中分組對(duì)低分組:RR=0.88,95%CI=0.56~1.39;高分組對(duì)低分組:RR=0.94,,95%CI=0.68~1.29),甚至在小于胎齡兒組呈現(xiàn)出一種保護(hù)效應(yīng)(高分組對(duì)低分組:RR=0.74,95%CI=0.57~0.94)。根據(jù)胎兒性別、孕婦年齡、孕前BMI進(jìn)行分層分析結(jié)果亦未發(fā)現(xiàn)孕前家用化學(xué)品使用與早產(chǎn)、低出生體重、小于胎齡兒之間有任何關(guān)聯(lián)。多重線性回歸模型結(jié)果顯示,孕前家用化學(xué)品使用與新生兒出生體重、身長、頭圍、胸圍等胎兒生長發(fā)育指標(biāo)之間的差異無統(tǒng)計(jì)學(xué)意義(均P>0.05)。孕早期家用化學(xué)品資料完整進(jìn)入分析的孕婦共計(jì)10269人,美白霜的使用率最高(28%),其他家用化學(xué)品的使用率相對(duì)較低(≤29%)。Logistic回歸分析結(jié)果顯示,鄉(xiāng)村地區(qū)的孕早期家用化學(xué)品使用率高于城鎮(zhèn)地區(qū),孕婦較低的文化程度、孕婦低齡、孕前低BMI、孕期焦慮、孕前半年服用過避孕藥、孕婦有吸煙史、孕婦有飲酒史、服用/注射過藥物是孕早期家用化學(xué)品使用較多的正向關(guān)聯(lián)因素,陰道流血是孕早期家用化學(xué)品使用較多的負(fù)向關(guān)聯(lián)因素。Logistic回歸結(jié)果顯示,孕早期家用化學(xué)品使用與低出生體重?zé)o統(tǒng)計(jì)學(xué)顯著關(guān)聯(lián)(使用組對(duì)幾乎不用組:RR=1.11,95%CI=0.83~1.49),與小于胎齡兒亦無統(tǒng)計(jì)學(xué)顯著關(guān)聯(lián)(使用組對(duì)幾乎不用組:RR=1.07,95%CI=0.85~1.33),甚至在早產(chǎn)組呈現(xiàn)出一種保護(hù)效應(yīng)(使用組對(duì)幾乎不用組:RR=0.72,95%CI=0.58~0.90)。根據(jù)胎兒性別、孕婦年齡、孕前BMI進(jìn)行分層分析結(jié)果亦未發(fā)現(xiàn)孕早期家用化學(xué)品使用與早產(chǎn)、低出生體重、小于胎齡兒呈現(xiàn)正向關(guān)聯(lián)。多重線性回歸模型分析,亦未發(fā)現(xiàn)孕早期家用化學(xué)品使用與新生兒出生體重、身長、頭圍、胸圍等生長發(fā)育指標(biāo)之間的差異有統(tǒng)計(jì)學(xué)意義(均P>0.05)。 結(jié)論 孕前家用化學(xué)品中美白霜的使用頻率最高(59.2%),其他家用化學(xué)品的使用頻率相對(duì)較低(≤35%)。孕婦的文化程度與孕前使用家用化學(xué)品顯著相關(guān),而孕婦低齡、孕前低BMI、有流產(chǎn)史、有婦科感染史、孕期抑郁、焦慮、孕前半年服用過避孕藥、有吸煙史、飲酒史、服用/注射過藥物是孕前使用家用化學(xué)品的正向關(guān)聯(lián)因素。未發(fā)現(xiàn)孕婦孕前家用化學(xué)品使用與3種不良妊娠結(jié)局、胎兒宮內(nèi)生長發(fā)育指標(biāo)之間存在顯著關(guān)聯(lián)。孕早期家用化學(xué)品中美白霜的使用頻率最高(28%),其他家用化學(xué)品的使用頻率相對(duì)較低(≤29%)。鄉(xiāng)村地區(qū)的孕早期家用化學(xué)品使用率高于城鎮(zhèn)地區(qū)。孕婦較低的文化程度、孕婦低齡、孕前低BMI、焦慮、孕前半年服用過避孕藥、有吸煙史、飲酒史、服用/注射過藥物是孕早期使用家用化學(xué)品的正向關(guān)聯(lián)因素,陰道流血是孕早期使用家用化學(xué)品的負(fù)向關(guān)聯(lián)因素。亦未發(fā)現(xiàn)孕婦孕早期家用化學(xué)品使用與3種不良妊娠結(jié)局、胎兒宮內(nèi)生長發(fā)育指標(biāo)之間存在任何顯著關(guān)聯(lián)。
[Abstract]:Purpose
The article describes the use of domestic chemicals before and after pregnancy , analyses the influencing factors of the use of domestic chemicals before and before pregnancy , and further discusses the association between the use of domestic chemicals and preterm birth , the low birth weight , the gestational age and the growth and development index of the fetus .
method
From October 2008 to October 2010 , the maternal and child health care institutions in Hefei , Wuhu and Ma On Shan in Anhui province were recruited to establish a health manual , and a complete pregnant woman was recorded . During the follow - up period , the maternal and child health records of pregnant women were collected from the Maternal and Child Health Record Table , which was prepared by the teaching and research laboratory , and the data of the pregnant women ' s demographic information , the pregnancy - related conditions , the poor lifestyle , the use of domestic chemicals before pregnancy and early pregnancy , the mental stress condition during pregnancy , etc . were collected .
To collect information about birth weight , body length , head circumference , chest circumference , gestational age , sex and so on , all pregnant women who participated in the study signed the informed consent form .
Using the linear regression model to analyze the correlation between the use of domestic chemicals and the growth and development index of the fetus in the early pregnancy and early pregnancy ;
Logistic regression model was used to analyze the influencing factors of the use of domestic chemicals before and after pregnancy , and to explore the association between the use of domestic chemicals and preterm birth , low birth weight and less than three adverse pregnancy outcomes in gestational age .
Results
Logistic regression showed that the use of domestic chemicals was significantly correlated with the use of domestic chemicals before pregnancy ( RR = 0.82 , 95 % CI = 0.59 - 1.14 ) .
High grouping ( RR = 0.80 , 95 % CI = 0.63 ~ 1.01 ) , there was no statistically significant association with low birth weight ( median group : RR = 0.88 , 95 % CI = 0.56 ~ 1.39 ;
High grouping ( RR = 0.94 , 95 % CI = 0.68 - 1.29 ) , even at less than the gestational age group presented a protective effect ( high grouping versus low grouping : RR = 0.74 , 95 % CI = 0.57 ~ 0.94 ) . The results of Logistic regression showed that the use of domestic chemicals in rural areas was significantly higher than that in urban areas ( RR = 1.11 , 95 % CI = 0.85 - 1.33 ) . The results of Logistic regression showed that the use of domestic chemicals in rural areas was significantly higher than that in urban areas ( RR = 1.11 , 95 % CI = 0.85 - 1.33 ) . There was no statistical difference between the use of domestic chemicals and the birth weight , body length , head circumference , chest circumference and other development indexes in the early pregnancy , according to the results of the analysis of the fetus sex , the age of the pregnant woman and the BMI before pregnancy .
Conclusion
The use frequency of domestic chemicals in prenatal home chemicals is the highest ( 59.2 % ) , and the frequency of use of other domestic chemicals is relatively low ( 鈮
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