本文選題：Wolffian腫瘤 + 病理學(xué)診斷��； 參考：《臨床與實(shí)驗(yàn)病理學(xué)雜志》2017年03期

【摘要】：目的 探討卵巢惡性Wolffian腫瘤的臨床病理學(xué)特征、診斷及鑒別診斷。方法 對(duì)1例卵巢惡性Wolffian腫瘤進(jìn)行HE及免疫組化Max Vision法染色,并進(jìn)行臨床病理觀察。結(jié)果 患者臨床表現(xiàn)為絕經(jīng)后陰道流血,術(shù)中可見左側(cè)卵巢囊實(shí)性腫瘤,鏡下腫瘤細(xì)胞呈立方形或短梭形,形態(tài)溫和,呈管狀、腺泡狀、裂隙狀或束狀排列,核分裂象易見(35/10 HPF)。免疫組化示腫瘤細(xì)胞CK、vimentin、CD10、Pax-8均呈陽性,EMA、CD117均呈灶陽性,Calretinin、α-inhibin、CD99、ER、PR、CK7、CK20、CD56、Napsin A均呈陰性,p53陽性率約3%,Ki-67增殖指數(shù)約30%。結(jié)論 卵巢惡性Wolffian腫瘤臨床罕見,核分裂活躍及高增殖指數(shù)可能是診斷惡性Wolffian腫瘤的重要指標(biāo)。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis and differential diagnosis of malignant ovarian Wolffian tumors.Methods A case of malignant ovarian Wolffian tumor was studied by HE and Max Vision immunohistochemical staining.Results the clinical manifestations of the patients were postmenopausal vaginal bleeding. The left ovarian cystic solid tumor was seen during the operation. Under microscope, the tumor cells were square or short fusiform, mild in shape, tubular, acinar, fissure or bundles, and mitosis was easy to be seen in 35% 10 HPFs.Immunohistochemistry showed that all the tumor cells were positive for pax-8 and EMA-CD117 were focal positive for Calretinin, and 偽 -inhibinus CD99ERT / PRCK7CK20 / CD56 / Napsin A were all negative for p53. The Ki-67 proliferative index was about 30%.Conclusion malignant ovarian Wolffian tumors are rare in clinic. Mitotic activity and high proliferative index may be important markers in the diagnosis of malignant Wolffian tumors.
【作者單位】： 廣西壯族自治區(qū)人民醫(yī)院病理科;
【分類號(hào)】：R737.3
，

本文編號(hào)：1758479