本文選題：圍絕經(jīng)期綜合征　切入點(diǎn)：米氮平　出處：《中國(guó)藥房》2015年33期

【摘要】：目的:觀察米氮平治療伴有睡眠障礙圍絕經(jīng)期綜合征的療效和安全性。方法:100例圍絕經(jīng)期患者隨機(jī)分為研究組(52例)和對(duì)照組(48例)。研究組患者給予米氮平片起始劑量15 mg,睡前1~2 h服用,每日1次,1周后增加劑量并維持至30 mg;對(duì)照組患者給予谷維素片10 mg,飯后服用,每日3次。兩組患者療程均為8周。觀察兩組患者治療前后漢密爾頓抑郁量表17項(xiàng)(HAMD-17)評(píng)分、匹茲堡睡眠質(zhì)量指數(shù)(PSQI)評(píng)分,并據(jù)此評(píng)價(jià)睡眠療效和抑郁療效,觀察2組的不良反應(yīng)發(fā)生情況。結(jié)果:治療后,研究組患者HAMD-17評(píng)分、PSQI評(píng)分均顯著低于同組治療前及對(duì)照組,且8周末4周末2周末,差異均有統(tǒng)計(jì)學(xué)意義(P0.05或P0.01)。研究組患者抑郁、睡眠總有效率顯著高于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。但研究組患者不良反應(yīng)發(fā)生率顯著高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:米氮平治療改善圍絕經(jīng)期綜合征的抑郁焦慮癥狀療效顯著,可改善睡眠,起效快速,但不良反應(yīng)有待進(jìn)一步觀察。
[Abstract]:Objective: to observe the efficacy and safety of mirtazapine in the treatment of peri-menopausal syndrome with sleep disorder.Methods 100 cases of perimenopausal patients were randomly divided into study group (n = 52) and control group (n = 48).The patients in the study group were given metozapine at the initial dose of 15 mg at 1h before bedtime, the dose was increased once a week and maintained to 30 mg, while the patients in the control group were given 10 mg oryzanol tablets three times a day after meals.The course of treatment was 8 weeks.Before and after treatment, 17 items of Hamilton Depression scale (Hamd-17) and Pittsburgh Sleep quality Index (PSQI) were evaluated.Results: after treatment, the HAMD-17 scores of the patients in the study group were significantly lower than those in the same group and the control group before treatment, and the differences were statistically significant (P0.05 or P0.01) at the end of the 8th weekend and the 4th weekend and the 2nd weekend.The total effective rate of depression and sleep in the study group was significantly higher than that in the control group (P 0.05).However, the incidence of adverse reactions in the study group was significantly higher than that in the control group (P 0.05).Conclusion: mirtazapine is effective in improving depression and anxiety symptoms of perimenopausal syndrome. It can improve sleep and take effect quickly, but the adverse reactions need to be further observed.
【作者單位】： 寧波市第二醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R711.75;R740

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 邱翠華;朱薛艷;;中藥對(duì)甲氨蝶呤治療未破裂型異位妊娠療效的影響[J];中醫(yī)藥臨床雜志;2006年02期

2 葉紅娟;;自擬活血解毒湯保留灌腸治療慢性盆腔炎84例[J];中醫(yī)藥臨床雜志;2006年06期

3 張菁;呂秀花;韓云鵬;;益氣固沖湯治療更年期功能失調(diào)性子宮出血46例[J];中醫(yī)藥臨床雜志;2007年01期

4 李，

本文編號(hào)：1724533