本文選題：妊娠期糖尿病　切入點：晚期糖基化終末產(chǎn)物　出處：《山東醫(yī)藥》2017年45期

【摘要】：目的觀察妊娠期糖尿病(GDM)孕婦肘靜脈血清、新生兒臍靜脈血清中晚期糖基化終末產(chǎn)物(AGE)及AGE受體(RAGE)水平的變化,探討其二者與GDM發(fā)病、新生兒早期神經(jīng)系統(tǒng)發(fā)育的關(guān)系。方法選取GDM孕婦80例(GDM組),按孕周匹配同期住院分娩糖耐量正常孕婦80例為對照組。采用ELISA法分別檢測兩組母體肘靜脈及新生兒臍靜脈血清中AGE、RAGE水平;出生72 h內(nèi),對新生兒行新生兒神經(jīng)行為測定(NBNA)評分;并對上述指標之間進行相關(guān)分析。結(jié)果 GDM組母體肘靜脈血清及新生兒臍靜脈血清中AGE、RAGE水平高于對照組(P均0.05)。GDM組新生兒主動肌張力、原始反射及NBNA總分高于對照組(P均0.05)。GDM組母體肘靜脈血清中AGE、RAGE水平分別與新生兒臍靜脈血清中AGE、RAGE水平呈正相關(guān)性(r分別為0.725、0.473,P均0.05)。GDM組母體肘靜脈血清中AGE、RAGE水平與NBNA評分呈負相關(guān)性(r分別為-0.415、-0.320,P均0.05)。GDM組新生兒臍靜脈血清中AGE、RAGE水平與NBNA評分呈負相關(guān)性(r分別為-0.294、-0.280,P均0.05)。結(jié)論 GDM母體肘靜脈血清及新生兒臍靜脈血清中AGE、RAGE水平升高,其與GDM發(fā)生及新生兒早期神經(jīng)系統(tǒng)缺陷均有關(guān)。
[Abstract]:Objective to observe the changes of serum level of cubital vein blood, advanced glycosylation end product (age) and AGE receptor (rage) in pregnant women with gestational diabetes mellitus (GDM), and to explore the relationship between them and the pathogenesis of GDM and the development of nervous system in the early stage of newborn.Methods 80 pregnant women with GDM and 80 normal pregnant women with normal glucose tolerance were selected as control group.ELISA method was used to detect the level of age in the serum of maternal cubital vein and neonatal umbilical vein, and the neonatal neurological behavior score was measured within 72 hours of birth, and the correlation between the above indexes was analyzed.Results the maternal cubital venous serum and the serum age level of umbilical vein in GDM group were higher than those in 0.05).GDM group.The total scores of primitive reflex and NBNA were higher than those of the control group. The level of age in maternal cubital vein serum of 0.05).GDM group was positively correlated with that of neonate umbilical vein serum. The correlation between age and age in maternal cubital vein serum of 0.05).GDM group was 0. 725 and 0. 473P = 0. 725 鹵0. 473P, respectively, and the level of NBNA in maternal cubital vein serum was significantly higher than that in both 0.05).GDM group and neonate umbilical vein serum.There was a negative correlation between the serum age level of umbilical vein and NBNA score in 0.05).GDM group (-0.294 鹵-0.280 P, P < 0.05).Conclusion the level of age rage in GDM maternal cubital venous blood and umbilical vein serum is increased, which is related to the occurrence of GDM and the early nervous system defect of newborn.
【作者單位】： 華北理工大學(xué)附屬醫(yī)院;華北理工大學(xué);
【基金】：河北省醫(yī)學(xué)適用跟蹤項目計劃(GL201646)
【分類號】：R714.256

【相似文獻】

相關(guān)期刊論文 前1條

1 麻慶玲;楊紅玲;朱春燕;;孕24~28周GDM孕婦部分急性時相反應(yīng)蛋白和胰島素功能的研究[J];中國婦幼保健;2014年10期

相關(guān)博士學(xué)位論文 前1條

1 王艷;妊娠期陰道微生物群落的分布特點與GDM孕婦妊娠結(jié)局的相關(guān)性分析[D];南方醫(yī)科大學(xué);2016年

相關(guān)碩士學(xué)位論文 前2條

1 楊琴;TGA對GDM孕婦外周血單個核細胞LPS/TLR4/NF-κB信號通路降調(diào)節(jié)的研究[D];安徽醫(yī)科大學(xué);2016年

2 李從青;GDM孕婦外周血單個核細胞在LPS刺激下TLR4的表達及其介導(dǎo)的NF-κB信號通路在GDM發(fā)病中的研究[D];安徽醫(yī)科大學(xué);2011年

，

本文編號：1719120