本文選題：橘荔散結(jié)片　切入點：GnRH-a　出處：《廣州中醫(yī)藥大學》2017年碩士論文

【摘要】：目的:觀察橘荔散結(jié)片聯(lián)合GnRH-a治療圍絕經(jīng)期子宮肌瘤合并異常子宮出血的臨床療效,為臨床運用中西醫(yī)結(jié)合方法治療此類患者提供臨床依據(jù)。方法:收集年齡在40-55歲,經(jīng)臨床明確診斷為子宮肌瘤合并異常子宮出血的女性患者共35例,按照隨機化原則分為中西結(jié)合組20例和西藥組15例。中西結(jié)合組給予橘荔散結(jié)片聯(lián)合GnRH-a,西藥組給予GnRH-a。GnRH-a于月經(jīng)第1天皮下注射,每28天為1周期,橘荔散結(jié)片每次口服4片,每天3次。兩組療程均為6月。治療前后分別記錄兩組患者中醫(yī)癥候及月經(jīng)情況積分、子宮及肌瘤體積、子宮內(nèi)膜厚度、血紅蛋白量并進行統(tǒng)計分析。結(jié)果:1.本研究表明,治療前中西結(jié)合組和西藥組在年齡、籍貫、婚姻、病程、病情程度、中醫(yī)證候積分及月經(jīng)情況評分、子宮及肌瘤體積、子宮內(nèi)膜厚度、血紅蛋白量方面比較差別無統(tǒng)計學意義(P0.05),具有可比性。2.經(jīng)"橘荔散結(jié)片聯(lián)合GnRH-a"及"GnRH-a"干預(yù)后,對比治療前,兩組患者中醫(yī)癥候積分及月經(jīng)情況評分均下降,子宮及肌瘤體積均縮小,子宮內(nèi)膜厚度均變薄,血紅蛋白量均升高,且中西醫(yī)結(jié)合組的上述療效優(yōu)于西藥組,差異具有統(tǒng)計學意義(P0.05)。3.中西結(jié)合組總有效率為100.00%,治愈率為20.00%,顯效率為65.00%,有效率為15.00%;西藥組總有效率為73.33%,治愈率為0.00%,顯效率為53.33%,有效率為20.00%。中西結(jié)合組總有效率高于西藥組26.67%,兩組療效對比差異比較具有統(tǒng)計學意義(P0.05),中西結(jié)合組療效優(yōu)于西藥組。結(jié)論:橘荔散結(jié)片聯(lián)合GnRH-a治療圍絕經(jīng)期子宮肌瘤合并異常子宮出血臨床療效較可觀,值得臨床推廣應(yīng)用。
[Abstract]:Objective: to observe the clinical effect of tangli Sanjie tablet combined with GnRH-a in the treatment of peri-menopausal uterine leiomyoma with abnormal uterine bleeding, and to provide clinical basis for the clinical treatment of this kind of patients with integrated traditional Chinese and western medicine.Methods: a total of 35 female patients aged 40-55 years with uterine leiomyoma complicated with abnormal uterine bleeding were collected. According to the principle of randomization, they were divided into Chinese and western combination group (n = 20) and western medicine group (n = 15).The combination group was given tangeri Sanjie tablet combined with GnRH-a, the western medicine group was subcutaneously injected with GnRH-a.GnRH-a on the 1st day of menstruation for 1 cycle every 28 days, and 4 tablets were taken orally, 3 times a day.The course of treatment in both groups was 6 months.Before and after treatment, the scores of TCM symptoms and menstruation, the volume of uterus and myoma, the thickness of endometrium, the amount of hemoglobin were recorded and analyzed statistically.The result is 1: 1.This study shows that before treatment, the combination of Chinese and Western medicine and western medicine group in age, place of origin, marriage, course of disease, degree of illness, TCM syndromes score and menstrual score, uterine and myoma volume, endometrial thickness,There was no significant difference in hemoglobin content (P 0.05), which was comparable. 2.After the intervention of "tangerine Lisanjie tablet combined with GnRH-a" and "GnRH-a", the scores of TCM symptoms and menstruation of the two groups decreased, the volume of uterus and myoma decreased, the thickness of endometrium became thinner, and the content of hemoglobin increased.And the combination of traditional Chinese and Western medicine group than the western medicine group, the difference is statistically significant P 0.05. 3.The total effective rate of the combination group was 100.00000, the cure rate was 20.00, the effective rate was 65.00 and the effective rate was 15.00.The total effective rate of the western medicine group was 73.33 and the cure rate was 0.000.The effective rate was 53.33 and the effective rate was 20.00.The total effective rate of the combination group was higher than that of the western medicine group (26.67%), and the difference between the two groups was statistically significant (P 0.05). The curative effect of the Chinese and Western combination group was better than that of the western medicine group.Conclusion: the clinical effect of tangli Sanjie tablet combined with GnRH-a in the treatment of peri-menopausal uterine leiomyoma with abnormal uterine hemorrhage is considerable and worthy of clinical application.
【學位授予單位】：廣州中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R737.33

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