本文選題：輔助生殖技術(shù)　切入點(diǎn)：枯萎卵　出處：《南方醫(yī)科大學(xué)學(xué)報(bào)》2017年07期

【摘要】：目的探究輔助生殖技術(shù)(ART)妊娠婦女中枯萎卵的發(fā)生率和影響因素。方法回顧性分析2012年1月~2015年12月在南方醫(yī)科大學(xué)南方醫(yī)院生殖中心行體外受精-胚胎移植臨床妊娠共2378例,包括早期胚胎停育和同期單胎活產(chǎn),其中胚胎停育根據(jù)有無(wú)胎芽分為胎芽組和枯萎卵組。比較枯萎卵組、胎芽組和活產(chǎn)組3組間基本信息,如女方年齡、男方年齡、體質(zhì)量指數(shù)(BMI)、基礎(chǔ)竇卵泡數(shù)(AFC)、基礎(chǔ)卵泡刺激素(b FSH)、b FSH/b LH比值、不孕年限、促性腺激素(Gn)用量及Gn天數(shù)、人絨毛膜促性腺激素(h CG)注射日雌二醇值、移植日內(nèi)膜厚度、獲卵數(shù)、移植優(yōu)胚率、移植后10~14 d血清β-h CG值、不孕類(lèi)型和流產(chǎn)次數(shù),以及不同移植周期、胚胎類(lèi)型、不孕因素、受精方式間枯萎卵發(fā)生率的比較。結(jié)果枯萎卵組的雙方年齡、BMI、不孕年限、不孕類(lèi)型、流產(chǎn)次數(shù)和活產(chǎn)組有顯著性差異;β-h CG在枯萎卵組胎芽組活產(chǎn)組(P=0.000);囊胚移植較卵裂期胚胎顯著增加枯萎卵的發(fā)生率(11.6%vs 5.6%,P=0.000);3組間其他參數(shù)無(wú)統(tǒng)計(jì)學(xué)差異(P0.05);經(jīng)多因素Logistic回歸分析,女方年齡、β-h CG和囊胚移植是枯萎卵發(fā)生的危險(xiǎn)因素。結(jié)論女方高齡、血清β-h CG下降和囊胚移植增加枯萎卵發(fā)生的風(fēng)險(xiǎn),枯萎卵的發(fā)生可能和早期胚胎發(fā)育的基因印記錯(cuò)誤有關(guān)。
[Abstract]:Objective to investigate the incidence and influencing factors of withered eggs in pregnant women with assisted reproductive technique (art). Methods 2378 cases of pregnancy in vitro fertilization and embryo transfer were retrospectively analyzed from January 2012 to December 2015 in the Reproductive Center of Southern Hospital of Southern Medical University. Including early embryo suspension and simultaneous single birth, in which embryo suspension was divided into embryonic bud group and withered egg group according to the presence of embryo buds. Basic information was compared among three groups: withered egg group, fetal bud group and live birth group, such as the age of the woman and the age of the male. Body mass index (BMI), number of basic antral follicles, ratio of basal follicle stimulating hormone (FSH) and FSH/b LH, age of infertility, dosage of gonadotropin (Gnn) and days of Gn, estradiol value of human chorionic gonadotropin (hCG) injection day, thickness of endometrium on the day of transplantation, and number of eggs obtained. The rate of excellent embryo transplantation, the serum 尾 -hCG value of 10 days and 14 days after transplantation, the type of infertility and the times of abortion, the different transfer cycles, the types of embryos, the factors of infertility, Results the BMIs, the years of infertility, the type of infertility, the age of both sides of the wilted egg group, There were significant differences in abortion frequency and live delivery group, 尾 -hCG in embryo bud group of withered egg group (P0. 000), blastocyst transfer significantly increased the incidence of withered egg compared with blastocyst embryo group (11. 6 vs 5. 6%), there was no significant difference in other parameters among the three groups (P0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05). The age of female, 尾 -hCG and blastocyst transplantation were the risk factors of wilt oocytes. Conclusion in old age, serum 尾 -hCG decrease and blastocyst transplantation increase the risk of wilting eggs, and the occurrence of withered eggs may be related to gene imprinting errors in early embryonic development.
【作者單位】： 南方醫(yī)科大學(xué)南方醫(yī)院婦產(chǎn)科生殖中心;
【基金】：國(guó)家科技支撐計(jì)劃項(xiàng)目(2013BAI12B01-7) 廣東省自然科學(xué)基金(1414050001657)~~
【分類(lèi)號(hào)】：R714.8

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