本文選題：孕期　切入點：陰道假絲酵母菌　出處：《現(xiàn)代預防醫(yī)學》2015年23期

【摘要】：目的對海南地區(qū)女性孕期陰道假絲酵母菌進行病原學調(diào)查,進一步了解菌種分布情況及探討相關危險因素,為防治妊娠女性合并外陰陰道假絲酵母菌病(VVC)的發(fā)生和優(yōu)生優(yōu)育提供理論依據(jù)。方法隨機采集1 512例2010年6月-2013年12月在門診產(chǎn)檢的妊娠女性陰道分泌物進行假絲酵母菌培養(yǎng)及菌種鑒定,并對其病例進行統(tǒng)計,了解相關影響因素并進行統(tǒng)計學分析。結(jié)果 (1)女性孕期陰道假絲酵母菌總的分離率是36.5%,其中白假絲酵母菌47.1%,光滑假絲酵母菌27.5%,熱帶假絲酵母菌4.3%;晚孕期女性陰道假絲酵母菌攜帶率明顯增加,高達49.3%。(2)分離出的白假絲酵母菌對兩性霉素B、5氟胞嘧啶的敏感性分別為99.2%、98.5%,對伏立康唑、氟康唑和伊曲康唑的敏感程度不一;非白假絲酵母菌對兩性霉素B、5氟胞嘧啶的敏感性均為100%,對唑類抗真菌藥的敏感性普遍不高。(3)孕前VVC史、人流史、血糖異常史的OR值(95%CI)依次是17.3(11.67~25.67)、3.79(2.78~5.18)、21.9(14.58~32.94)。結(jié)論海南地區(qū)女性孕期陰道假絲酵母攜帶具有分離率高、菌群以白假絲酵母菌為主,非白色假絲酵母菌有上升的趨勢的特征;分離株的耐藥性較普遍。為防止對妊娠結(jié)局的不利影響,需要早期給予干預,合理選擇抗真菌藥物,并加強優(yōu)生優(yōu)育知識的宣講。
[Abstract]:Objective to investigate the etiology of Candida vaginalis during pregnancy in Hainan, and to investigate the distribution of Candida vaginalis and its risk factors. To provide theoretical basis for the prevention and treatment of vulvovaginal candidiasis (VVCC) in pregnant women with vulvovaginal candidiasis. Methods A total of 1 512 cases of vaginal secretions of pregnant women from June 2010 to December 2013 were collected randomly for false birth. Culture and identification of mycelia, And make statistics on their cases, Results the total isolation rate of Candida vaginalis during pregnancy was 36.5%, including 47.1% of Candida albicans, 27.5m of Candida smooth, 4.3% of Candida tropicalis; The carrying rate of Candida cerevisiae increased significantly. The sensitivities of Candida albicans isolated to amphotericin Bn5 fluorocytosine were 99.2% and 98.5%, respectively, and the sensitivities to Veconazole, fluconazole and itraconazole were different. The sensitivity of non-Candida cerevisiae to amphotericin B _ (5) fluorocytosine was 100, and the sensitivity to antifungal agents of azolium was not high. (3) the history of VVC and abortion before pregnancy. The OR value (95 CI) of the history of abnormal blood glucose was 17.3C 11.6725.67C 3.792.785.18U 21.9U 14.5858.32.940.Conclusion the rate of isolation of Candida vaginalis during pregnancy in Hainan area is high, the bacteria group is mainly Candida albicans, and the non-white Candida cerevisiae has the characteristic of rising trend. In order to prevent the adverse effects on pregnancy outcome, early intervention should be given, antifungal drugs should be reasonably selected, and the knowledge of eugenics and eugenics should be strengthened.
【作者單位】： 中南大學基礎醫(yī)學院免疫系;海南醫(yī)學院熱帶醫(yī)學與檢驗醫(yī)學院;海南省干部療養(yǎng)院;海南省屯昌縣人民醫(yī)院;
【基金】：國家自然科學基金資助(30760001,31260225)
【分類號】：R714.251;R446.5

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本文編號：1670611