本文選題：促性腺激素平抑因子(Gn　切入點(diǎn)：SAF)　出處：《吉林大學(xué)》2017年碩士論文

【摘要】：目的:通過(guò)測(cè)定各類(lèi)患者血清Gn SAF、AMH及性激素等指標(biāo),記錄各類(lèi)患者的年齡等臨床資料,分析各指標(biāo)間的相關(guān)性,探討Gn SAF在預(yù)測(cè)卵巢儲(chǔ)備功能的臨床價(jià)值。方法:將卵巢功能不同的244例患者作為研究對(duì)象,按照分組標(biāo)準(zhǔn)分為卵巢高反應(yīng)組111例、卵巢反應(yīng)低下組73例、正常反應(yīng)組60例。檢測(cè)3組患者的基礎(chǔ)FSH、LH、AMH、E2、及Gn SAF,記錄3組患者的竇狀卵泡數(shù)及年齡分別進(jìn)行組間差異性分析,并做相關(guān)性分析。應(yīng)用SPSS19.0軟件分析三個(gè)組別血清Gn SAF有無(wú)差異,用spearman相關(guān)系數(shù)分析Gn SAF與其他指標(biāo)間的相關(guān)性。結(jié)果:(1)血清Gn SAF水平在卵巢高反應(yīng)組、卵巢低反應(yīng)組及正常反應(yīng)組之間差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),卵巢高反應(yīng)組的患者血清Gn SAF含量高于卵巢正常反應(yīng)的患者血清Gn SAF和卵巢低反應(yīng)組患者血清Gn SAF濃度,但差異性無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);(2)AMH、年齡及基礎(chǔ)激素指標(biāo)在卵巢低反應(yīng)組、卵巢高反應(yīng)組及卵巢正常反應(yīng)組之間差異有統(tǒng)計(jì)學(xué)意義(P0.01)。(3)AMH與血清FSH、年齡等有負(fù)相關(guān)性(r=-0.403,p=0.000;r=-0.053,P0.01),具有統(tǒng)計(jì)學(xué)意義,與LH水平、E2水平、AFC等有正相關(guān)性,有統(tǒng)計(jì)學(xué)意義。(4)血清Gn SAF水平與AMH水平、FSH水平、LH水、E2水平、AFC等指標(biāo)相關(guān)性無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論:(1)血清Gn SAF水平與預(yù)測(cè)卵巢儲(chǔ)備功能無(wú)相關(guān)性,需加大樣本量排除其他影響因素進(jìn)行深度研究。(2)AMH及AFC與年齡、FSH等各個(gè)指標(biāo)均有顯著相關(guān)性。(3)在預(yù)測(cè)卵巢功能方面,聯(lián)合抗苗勒氏管激素及竇狀卵泡數(shù)等多個(gè)指標(biāo)能取得更好的效果。
[Abstract]:Objective: to record the age and other clinical data of patients by measuring serum GnSAFAMH and sex hormone, and to analyze the correlation between them. To explore the clinical value of Gn SAF in predicting ovarian reserve function. Methods: one hundred and forty-four patients with different ovarian function were divided into ovarian hyperreactive group (n = 111) and ovarian low response group (n = 73). 60 cases of normal response group. The basic FSHLHAMHU E2 and GnSAF were detected, and the number of antral follicles and age of the three groups were recorded, and the correlation analysis was made. The serum Gn SAF of the three groups was analyzed by SPSS19.0 software. The correlation between Gn SAF and other indexes was analyzed by spearman correlation coefficient. There was no significant difference between the ovarian low response group and the normal response group. The serum Gn SAF level in the ovarian hyperreactive group was higher than that in the ovarian normal reaction group and the ovarian low reaction group. The serum Gn SAF level in the ovarian hyperreactive group was higher than that in the ovarian normal response group. However, there was no significant difference in AMH between the two groups. There were significant differences in age and basal hormone levels between ovarian low response group, ovarian hyperactive group and ovarian normal response group. There was a negative correlation between AMH and FSHs in serum, age, age, etc. There was a significant difference between age and age, there was a significant difference between age and age, and there was a significant difference between the age and the age of P0. 403p0. 000r-0. 053. There was no significant correlation between serum Gn SAF level and AMH level, LH level, E2 level and AFC level. Conclusion there was no correlation between serum Gn SAF level and ovarian reserve function. It is necessary to increase the sample size and exclude other influencing factors for in-depth study. There is a significant correlation between AFS, AMH and AFC, etc.) in predicting ovarian function, The combination of anti-Mullerian tube hormone and antral follicle number can achieve better results.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R711.6

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