本文選題：妊娠滋養(yǎng)細胞疾病　切入點：maspin　出處：《中國婦產(chǎn)科臨床雜志》2015年04期 　論文類型：期刊論文

【摘要】：目的探討maspin和c-erbB-2在妊娠滋養(yǎng)細胞疾病中的表達及臨床意義。方法收集225例葡萄胎患者,隨訪3~27個月,27例發(fā)展為侵蝕性葡萄胎,12例發(fā)展為絨毛膜癌。采用免疫組化PV9000二步法檢測24例正常早期妊娠(對照組)、49例葡萄胎(葡萄胎組)、39例妊娠滋養(yǎng)細胞腫瘤(侵葡+絨癌組)maspin和c-erbB-2的表達。結果葡萄胎組maspin陽性表達率(65.3%,32/49)與對照組(91.7%,22/24)及侵葡+絨癌組(35.9%,14/39)比較,差異有統(tǒng)計學意義(P0.05)。hCG105 U/L、子宮體積孕周及卵巢黃素囊腫直徑6cm組maspin陽性率分別為34.6%(18/52)、37.0%(20/54)和36.6%(15/41),均低于無上述高危因素組(P0.05)。葡萄胎組c-erbB-2陽性表達率(53.1%,26/49)與侵葡+絨癌組(74.4%,29/39)比較,差異有統(tǒng)計學意義(P0.05)。子宮體積孕周組c-erbB-2陽性表達率(74.1%,40/54)與子宮體積≤孕周組(44.1%,15/34)比較,差異有統(tǒng)計學意義(P0.05)。葡萄胎組maspin與c-erbB-2的表達呈負相關(r=-0.270,P0.05)。侵葡+絨癌組FIGO預后評分≥7分組maspin表達較7分組明顯下降(P0.05)。結論maspin和c-erbB-2可作為預測葡萄胎惡變的參考指標,maspin的檢測可能對妊娠滋養(yǎng)細胞疾病預后評估有一定的參考意義。
[Abstract]:Objective to investigate the expression and clinical significance of maspin and c-erbB-2 in gestational trophoblastic diseases. 27 cases of invasive hydatidiform mole were followed up for 3 ~ 27 months. Immunohistochemical PV9000 two-step method was used to detect 24 cases of normal early pregnancy (control group 49 cases of hydatidiform mole) (hydatidiform mole group 39 cases of gestational trophoblastic tumor). (expression of maspin and c-erbB-2 in invasive staphylococcal choriocarcinoma group. Results the positive rate of maspin expression in hydatidiform mole group was 65.3 / 49) compared with that in control group (91.72.22 / 24) and invasive staphylococcal carcinoma group (35.914 / 39). The positive rates of maspin in gestational weeks of uterine volume and in 6cm diameter of ovarian flavin cysts were 34.6 / 1852% and 37.0% 20 / 54, respectively, and 36.6% of 41 cases were lower than those of non-high risk factors group (P0.055.The positive expression rate of c-erbB-2 in hydatidiform mole group was 53.11% 2649), compared with that in invasive staphylochoriocarcinoma group (74.440 / 2939). The positive expression rate of c-erbB-2 was 74.1% (40 / 54) in gestational age group and 44.1 / 34% in uterus volume 鈮，

本文編號：1625464