本文選題：復(fù)發(fā)性流產(chǎn)　切入點：復(fù)方固沖壽胎湯　出處：《廣西醫(yī)科大學(xué)學(xué)報》2016年06期 　論文類型：期刊論文

【摘要】：目的:探討復(fù)方固沖壽胎湯聯(lián)合主動免疫治療不明原因復(fù)發(fā)性流產(chǎn)患者的臨床效果。方法:選取2015年1月至2016年3月就診于內(nèi)蒙古醫(yī)科大學(xué)附屬醫(yī)院產(chǎn)科的不明原因復(fù)發(fā)性流產(chǎn)患者56例,按照隨機(jī)數(shù)字表法分為研究組和對照組,每組各28例。對照組給予主動免疫治療,研究組采用復(fù)方固沖壽胎湯聯(lián)合主動免疫治療。觀察兩組患者的治療效果,治療前、后免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、補(bǔ)體C3(C3)、補(bǔ)體C4(C4)、T淋巴細(xì)胞亞群CD4~+、CD8~+免疫指標(biāo)水平及血絨毛膜促性腺激素(HCG)和孕酮變化。比較兩組治療中不良反應(yīng)發(fā)生情況。結(jié)果:研究組治療總有效率為85.71%,顯著高于對照組的60.71%(P0.05)。治療后兩組患者的IgG、IgA、IgM、C3、CD4~+、CD4~+/CD8~+指標(biāo)水平均較治療前顯著降低(均P0.05),且研究組降低程度較對照組更加顯著(P0.05)。治療后,兩組患者的CD8~+指標(biāo)水平及HCG、孕酮水平均較治療前顯著升高(均P0.05),且研究組升高程度較對照組更加顯著(P0.05)。兩組患者均無明顯不良反應(yīng)情況發(fā)生。結(jié)論:復(fù)方固沖壽胎湯聯(lián)合主動免疫治療不明原因復(fù)發(fā)性流產(chǎn)療效可靠,可改善患者免疫功能,提高妊娠成功率,且安全性較高,值得臨床推廣應(yīng)用。
[Abstract]:Objective: to investigate the clinical effect of compound Guchong Shoutai decoction combined with active immunotherapy for patients with unexplained recurrent abortion. Methods: from January 2015 to March 2016, we selected the unknown obstetrics department of affiliated Hospital of Inner Mongolia Medical University. 56 cases of recurrent abortion, According to the method of random number table, the study group and the control group were divided into two groups, 28 cases in each group. The control group was given active immunotherapy, and the study group was treated with compound Guchong Shoutai decoction combined with active immunotherapy. The changes of immunoglobulin G _ 4 ~ T lymphocyte subsets, serum chorionic gonadotropin (HCG) and progesterone (progesterone) were compared between the two groups, including immunoglobulin G _ 4, immunoglobulin A, immunoglobulin A, immunoglobulin A, immunoglobulin A, complement C _ 3C _ 3, complement C _ 4 ~ + C _ 4T lymphocyte subsets and serum chorionic gonadotropin (HCG) and progesterone. Results: the total effective rate of treatment in the study group was 85.71, which was significantly higher than that in the control group (60.71%, P 0.05). After the treatment, the level of IgGN IgMN IgMN, CD4 ~ / / CD8 ~, was significantly lower in the study group than that in the control group (all P 0.05, P 0.05). After treatment, the degree of decrease in the study group was more significant than that in the control group (P 0.05). The levels of CD8 ~ index, HCG and progesterone in both groups were significantly higher than those before treatment (all P0.05, and the degree of increase in the study group was more significant than that in the control group). There were no significant adverse reactions in both groups. Conclusion: compound Guchongshou has no significant adverse reactions. Fetal decoction combined with active immunotherapy is effective in the treatment of recurrent abortion with unknown causes. It can improve the immune function of patients, improve the success rate of pregnancy, and the safety is higher, which is worthy of clinical application.
【作者單位】： 內(nèi)蒙古醫(yī)科大學(xué)附屬醫(yī)院產(chǎn)科;
【分類號】：R714.21

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本文編號：1618025