本文選題：宮頸癌　切入點：細胞學檢查　出處：《新疆醫(yī)科大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:探討TCT、HPV、端粒酶基因(hTERC)、C-MYC基因在新疆維吾爾族婦女宮頸病變篩查中的臨床價值。方法:收集1000例新疆維吾爾族婦女的宮頸脫落細胞行液基細胞學檢測(TCT)、高危人乳頭瘤病毒檢測(HPV)、hTERC、C-MYC基因檢測,任一指標陽性,行陰道鏡下活檢。結(jié)果:隨著宮頸細胞學及組織學病變程度的增加,HPV、hTERC、C-MYC基因陽性率逐漸增加(P0.05),HPV、hTERC、C-MYC基因擴增在CINⅡ及以上級別病變中的陽性率高于CINⅠ及以下病變(P0.05)。HPV陽性組中hTERC、C-MYC基因的擴增高于HPV陰性組,兩組比較差異有統(tǒng)計學意義(P0.05)。在檢測宮頸高級別病變(≥CINⅡ),hTERC、C-MYC基因有較高的敏感度、特異度、陰性預(yù)測值,TCT、HPV、hTERC、C-MYC基因檢測宮頸CINⅡ及以上病變的受試者工作特征曲線(ROC)下面積分別為0.657,0.639,0.879,0.835。結(jié)論:1.hTERC及C-MYC基因的擴率隨著宮頸病變程度加重而增加,可作為預(yù)測宮頸病變進展的重要生物學指標。2.HPV感染與hTERC、C-MYC基因異常擴增之間呈正相關(guān),hTERC、C-MYC基因異常擴增在宮頸癌的發(fā)生起著重要作用。3.hTERC、C-MYC基因檢測在宮頸CINⅡ及以上高度病變中有較高的篩查價值,對宮頸高度病變的篩查有意義。
[Abstract]:Objective: to investigate the clinical value of TCTH HPVand telomerase gene hTERCU C-MYC gene in screening cervical lesions of Uygur women in Xinjiang. Methods: 1000 cases of Xinjiang Uygur women with cervical exfoliated cells were collected for liquid-based cytological examination. Detection of papillomavirus in HPV-hTERCU C-MYC gene, Either indicator is positive, Results: with the increase of the degree of cervical cytology and histologic lesion, the positive rate of HPV-hTERCnC-MYC gene increased gradually. The positive rate of HPV-hTERCnC-MYC gene amplification in CIN 鈪，

本文編號：1607574