本文選題：生殖技術(shù)　切入點(diǎn)：輔助　出處：《國際生殖健康/計(jì)劃生育雜志》2016年06期 　論文類型：期刊論文

【摘要】：目的:探討反復(fù)種植失敗(RIF)患者凍融胚胎移植(FET)周期中藥左歸丸臨床應(yīng)用效果。方法:選擇2014年6月—2015年12月于蘭州大學(xué)第一醫(yī)院生殖醫(yī)學(xué)�？漆t(yī)院采用促性腺激素釋放激素激動劑(GnRHa)降調(diào)節(jié)激素替代方案準(zhǔn)備子宮內(nèi)膜進(jìn)行FET周期的RIF患者80例,根據(jù)隨機(jī)數(shù)字表法,分為中藥組(40例)和對照組(40例)。中藥組予GnRHa降調(diào)節(jié)4個(gè)周期,每個(gè)周期間加用中藥左歸丸14 d。對照組只予GnRHa降調(diào)節(jié)4個(gè)周期。觀察2組患者降調(diào)節(jié)期間臨床癥狀,人絨毛膜促性腺激素(h CG)日和移植日血清性激素水平及臨床妊娠率,血流指標(biāo)。結(jié)果:2組患者h(yuǎn)CG日雌二醇(E_2)、黃體生成激素(LH)及移植日孕激素(P)比較差異無統(tǒng)計(jì)學(xué)意義(均P0.05)。中藥組移植日E_2、胚胎種植率及臨床妊娠率均高于對照組(均P0.05)。與對照組比較,中藥組子宮內(nèi)膜基底動脈阻力指數(shù)(RI)降低,陰道超聲顯示子宮內(nèi)膜-肌層交界(EMI)區(qū)回聲有所改善,差異有統(tǒng)計(jì)學(xué)意義(均P0.05),兩組間內(nèi)膜基底區(qū)搏動指數(shù)(PI)及血流分支差異無統(tǒng)計(jì)學(xué)意義(均P0.05)。降調(diào)期予中藥治療后潮熱出汗、腰膝酸軟等腎陰虛癥狀明顯改善(均P0.05)。結(jié)論:中藥左歸丸可協(xié)調(diào)激素水平,改善降調(diào)節(jié)期間腎陰虛癥狀,改善子宮內(nèi)膜血流,從而增加胚胎種植率。
[Abstract]:Objective: to investigate the clinical application effect of Zuogui Pill, a traditional Chinese medicine for frozen and thawed embryo transfer (FET) cycle in patients with recurrent failed implantation RIFs. Methods: gonadotropin gonadotropin was used in the first Hospital of Reproductive Medicine of Lanzhou University from June 2014 to December 2015. The hormone releasing hormone agonist (GnR Ha) down-regulated hormone replacement regimen was used to prepare the endometrium for FET cycle in 80 patients with RIF. According to the random digital table method, it was divided into Chinese medicine group (n = 40) and control group (n = 40). The traditional Chinese medicine group was given GnRHa descending regulation for 4 cycles. Zuo Gui Pill was added every week for 14 days. The control group was given only 4 cycles of GnRHa down-regulation. The clinical symptoms, serum sex hormone level and clinical pregnancy rate were observed in the two groups during the down-regulation period, the day of HCG and the day of transplantation. Results there was no significant difference in serum estradiol, luteinizing hormone (LH) and progesterone (P < 0.05) between the two groups on the day of hCG. The embryo implantation rate and the clinical pregnancy rate in the traditional Chinese medicine group were higher than those in the control group (P < 0.05). Compared with the control group, In the traditional Chinese medicine group, the resistance index of endometrium basilar artery (RI) was decreased, and the echo of endometrium-myometrium junction (EMII) area was improved by vaginal ultrasound. The difference was statistically significant (P 0.05), and there was no significant difference between the two groups (P0. 05) and blood flow branches (P0. 05%, P 0. 05). After the treatment of traditional Chinese medicine, there was no significant difference between the two groups in the perspiration of hot flashes. Conclusion: Zuo Gui Pill can coordinate hormone level, improve kidney yin deficiency symptom, improve endometrial blood flow and increase embryo implantation rate.
【作者單位】： 蘭州大學(xué)第一醫(yī)院生殖醫(yī)學(xué)專科醫(yī)院;甘肅中醫(yī)藥大學(xué)附屬醫(yī)院針灸中心;
【基金】：甘肅省省青年科技基金計(jì)劃(1606RJYA273)
【分類號】：R714.8

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