本文選題：不明原因不孕　切入點(diǎn)：短時(shí)受精　出處：《南京醫(yī)科大學(xué)學(xué)報(bào)(自然科學(xué)版)》2015年05期 　論文類型：期刊論文

【摘要】：目的 :了解3周期以上宮腔內(nèi)人工控授精(IUI)失敗的不明原因,探討不孕夫婦采取何種卵子受精方式更為安全有效。方法:回顧性分析本中心5年間3周期以上IUI失敗的不明原因不孕共321例。根據(jù)不孕夫婦對(duì)于卵子受精方式的選擇,將其分為3組:體外受精(IVF)(備Rescue-ICSI)組(213例)、一半行卵細(xì)胞胞漿內(nèi)單精子注射(Half-ICSI)組(69例)、卵細(xì)胞胞漿內(nèi)單精子注射(ICSI)組(39例)。結(jié)果:3組中年齡、基礎(chǔ)促卵泡激素(FSH)、促性腺激素(Gn)天數(shù)、Gn用量無統(tǒng)計(jì)學(xué)差異。IVF組婦女不孕年限與其他兩組相比有差異,Half-ICSI組婦女竇卵泡計(jì)數(shù)和獲卵數(shù)較其他兩組多,ICSI組最少。IVF完全不受精發(fā)生率為18.8%(53/282)。3組總受精率、卵裂率無統(tǒng)計(jì)學(xué)差異,3組臨床妊娠率、種植率和活產(chǎn)率相似,但3組的優(yōu)質(zhì)胚胎率、流產(chǎn)率有統(tǒng)計(jì)學(xué)差異。其中IVF(備Rescue-ICSI)組優(yōu)質(zhì)胚胎率高于ICSI組,而流產(chǎn)率較Half-ICSI組低(P0.05)。結(jié)論:對(duì)于不明原因不孕婦女卵子受精方式的選擇,與Half-ICSI和ICSI相比,IVF后短時(shí)受精聯(lián)合補(bǔ)救ICSI是一個(gè)相對(duì)更安全、經(jīng)濟(jì)、有效的受精方式。
[Abstract]:Objective: to understand the unknown causes of the failure of IUI in human labor control insemination for more than 3 cycles. Methods: a total of 321 infertile couples who had failed IUI for more than 3 cycles in 5 years were analyzed retrospectively. They were divided into three groups: in vitro fertilization (IVF) group (n = 213), half of them were treated with Half-ICSI (n = 69) and 39 with ICSI (intracytoplasmic sperm injection) group (n = 39). There was no significant difference in the dosage of Gn between the basic follicle stimulating hormone (FSH) and gonadotropin (Gn). There was no significant difference in the number of infertile women in the IVF group compared with the other two groups. The number of antral follicles and the number of eggs obtained in the Half-ICSI group were less than those in the other two groups. The rate of fertilization was 18. 8% in 53 / 282. 3 group, and the fertilization rate was 18. 8% in 53 / 282. 3 group. There was no statistical difference in cleavage rate. The clinical pregnancy rate, implantation rate and live birth rate were similar among the three groups, but there were significant differences in the rate of high quality embryo and abortion in the three groups, in which the rate of high quality embryo in IVF (Rescue-ICSI) group was higher than that in ICSI group. The abortion rate was lower than that in Half-ICSI group (P 0.05). Conclusion: compared with Half-ICSI and ICSI, short term fertilization combined with ICSI is a more safe, economical and effective fertilization method for unexplained infertile women.
【作者單位】： 南京醫(yī)科大學(xué)第一附屬醫(yī)院生殖醫(yī)學(xué)中心;
【基金】：江蘇省衛(wèi)生廳科教興衛(wèi)工程項(xiàng)目(ZX201110) 江蘇省高校優(yōu)勢(shì)學(xué)科(PAPD)
【分類號(hào)】：R711.6

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 丁衛(wèi),劉嘉茵,錢云,楊乃明,冒韻東;不明原因原發(fā)性不孕者宮腔內(nèi)人工授精失敗后治療方案的選擇[J];中華男科學(xué)雜志;2004年10期

2 嚴(yán)正杰;蔡令波;馮婷;馬龍;陳娟;王Z，

本文編號(hào)：1589203