本文選題：傳代效應　切入點：生殖內(nèi)分泌疾病　出處：《上海交通大學學報(醫(yī)學版)》2017年02期 　論文類型：期刊論文

【摘要】：正上海交通大學醫(yī)學院附屬和平婦幼保健院黃荷鳳院長領(lǐng)銜的課題組發(fā)現(xiàn),女性妊娠前高雄激素癥可能增加子代糖代謝異常的風險,而表觀遺傳改變的傳代效應可能是其分子機制之一。這項研究成果近日在線發(fā)表于Cell出版社和The Lancet雜志支持的EBio Medicine雜志。高雄激素癥是育齡期婦女常見的生殖內(nèi)分泌疾病之一,其發(fā)生率在不孕人群中高達15%。既往的研究表明,卵泡內(nèi)過多的雄激素干擾卵子發(fā)育潛能,并進一步影響受精和胚胎發(fā)育。近年來,通過輔助生殖技術(shù)的應用,高雄激素癥
[Abstract]:The research group headed by Huang Hefeng, director of Heping Maternal and Child Health Institute, affiliated to the School of Medicine of Shanghai Jiaotong University, found that prepregnancy hyperandrogen may increase the risk of abnormal glucose metabolism in offspring. The epigenetic effect may be one of its molecular mechanisms. The study was published online in the journal EBio Medicine, supported by Cell Press and The Lancet. Hyperandrogenia is one of the most common reproductive endocrine diseases in women of reproductive age. Previous studies have shown that too much androgen in the follicle interferes with egg development potential and further affects fertilization and embryo development. In recent years, the use of assisted reproductive technology has led to hyperandrogenia
【分類號】：R714.2

【相似文獻】

相關(guān)期刊論文 前1條

1 李海艷;蔡德培;;環(huán)境內(nèi)分泌干擾物對基因甲基化的影響[J];中國生物化學與分子生物學報;2014年01期

相關(guān)博士學位論文 前1條

1 唐莉莉;宮外生長遲緩對肺血管影響及傳代效應的表觀遺傳機制研究[D];浙江大學;2015年

，

本文編號：1585232