本文選題：促排卵　切入點(diǎn)：卵巢儲(chǔ)備功能下降　出處：《實(shí)用臨床醫(yī)藥雜志》2016年05期 　論文類型：期刊論文

【摘要】：目的觀察和分析不同促排卵方法對(duì)卵巢儲(chǔ)備功能下降(DOR)患者的療效。方法選取120例行體外受精-胚胎移植(IVF-ET)術(shù)的DOR患者,分別應(yīng)用促性腺激素釋放激素激動(dòng)劑(GnRH-a)長(zhǎng)方案(A組,39個(gè)周期)、GnRH-a短方案(B組,45個(gè)周期)及促性腺激素釋放激素拮抗劑(GnRH-ant)方案(C組,36個(gè)周期)進(jìn)行促排卵。對(duì)3組患者的促性腺激素(Gn)用藥量及用藥時(shí)間,注射人絨毛膜促性腺激素(h CG)日的血清黃體生成素(LH)、雌二醇(E2)水平,子宮內(nèi)膜厚度及獲卵數(shù),受精率、卵裂率、種植率和臨床妊娠率進(jìn)行比較。結(jié)果 A組患者的Gn用藥時(shí)間和用藥量均顯著多于B組和C組,且C組患者的Gn用藥時(shí)間顯著長(zhǎng)于B組(q=2.756~3.936,P0.05),B組患者在注射h CG日的血清E2水平顯著高于A組和C組(q=2.638~3.145,P0.05)。3組患者的獲卵數(shù)、受精數(shù)、卵裂數(shù)、種植率、臨床妊娠率均無顯著差異(P0.05)。結(jié)論在DOR患者IVF-ET術(shù)中應(yīng)用GnRH-a短方案可減少Gn用量和使用時(shí)間,改善患者血清激素水平。
[Abstract]:Objective to observe and analyze the efficacy of different ovulation promotion methods in patients with ovarian reserve dysfunction. Methods 120 DOR patients undergoing IVF-ETS were selected. Ovulation was induced by gonadotropin releasing hormone agonist GnRH-a (GnRH-a) long regimen A, GnRH-a short regimen B (45 cycles) and gonadotropin releasing hormone antagonist (GnRH-antant) group C (36 cycles). The amount of gonadotropin (Gn) used and the duration of the treatment, Serum luteinizing hormone (LHH), estradiol E _ 2 (E _ 2), endometrial thickness and egg count, fertilization rate, cleavage rate, serum luteinizing hormone (LHH) and estradiol E _ 2 (E _ 2) on the day of human chorionic gonadotropin (hCG) injection. Results the duration and dosage of Gn in group A were significantly longer than those in group B and C. The serum E2 level in group C was significantly longer than that in group B (2.756 ~ 3.936 ~ 3.936 ~ 3.936) on the day of hCG injection, which was significantly higher than that in group A and C (2.638 ~ 3.145p _ 0.05C), and the number of oocytes, fertilization, cleavage and implantation rate were significantly higher in group C than in group B, and the serum E _ 2 level in group B was significantly higher than that in group A and C, respectively. There was no significant difference in clinical pregnancy rate (P 0.05). Conclusion the short regimen of GnRH-a during IVF-ET in DOR patients can reduce the dosage and duration of Gn, and improve the serum hormone level in patients with IVF-ET.
【作者單位】： 湖北省婦幼保健院;
【分類號(hào)】：R714.8

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