發(fā)布時(shí)間：2018-03-08 11:19

  本文選題：大鼠　切入點(diǎn)：聚丙烯　出處：《現(xiàn)代婦產(chǎn)科進(jìn)展》2017年04期 　論文類型：期刊論文

【摘要】：目的:觀察SIS和聚丙烯網(wǎng)片植入大鼠腹壁后局部組織形態(tài)中長(zhǎng)期的改變和區(qū)別。方法:60只成年SD大鼠隨機(jī)分為3組(每組20只),在大鼠腹壁形成2cm×2cm人工缺損,將聚丙烯合成網(wǎng)片(A組)、SIS生物網(wǎng)片(B組)植入大鼠腹壁后,與無網(wǎng)片植入組(C組)對(duì)比。術(shù)后3、9、15、21月,觀察網(wǎng)片植入局部宏觀和微觀(電鏡下)的形態(tài)學(xué)的改變。結(jié)果:術(shù)后SD大鼠減損例數(shù):A組4例,B組3例,C組3例,共10例,三組間無差異(P0.05)。隨著時(shí)間延長(zhǎng),術(shù)后各組均有不同程度的修復(fù)。聚丙烯網(wǎng)片組增生明顯,但異物感最強(qiáng),腹壁僵硬,觸摸時(shí)有明顯的沙粒感;SIS網(wǎng)片組柔軟、舒適,但有較為明顯的薄弱感;對(duì)照組縫合處與周圍組織觸感相同,偶及疤痕或結(jié)節(jié)。電鏡下:聚丙烯網(wǎng)片組成纖維細(xì)胞增殖更為活躍,數(shù)量也較多,組織較為緊密,膠原纖維增生多且致密,膠原纖維直徑粗,但異物界限稍有模糊,多層細(xì)胞管壁的較大血管,管腔逐漸增大,管壁逐漸增厚;SIS生物網(wǎng)片組較為稀疏,散亂,細(xì)胞數(shù)較少,膠原纖維增生效果最差,斷裂模糊,組織內(nèi)異物界限逐漸模糊、質(zhì)地變薄變淡,有消失趨勢(shì),血管增生最少,管壁最薄,管腔也最小,周圍組織較少;對(duì)照組成纖維細(xì)胞增生活躍,膠原纖維致密,血管增生較多,未見明顯異物。結(jié)論:聚丙烯網(wǎng)片組組織增生明顯,但異物感強(qiáng);SIS網(wǎng)片組織相容性良好,但增生不佳,提供張力的結(jié)締組織較為薄弱。開發(fā)同時(shí)具有各自優(yōu)點(diǎn)的網(wǎng)片將是繼續(xù)研究和應(yīng)用盆底生物網(wǎng)片的方向。
[Abstract]:Objective: to observe the long-term changes and differences of local histomorphology after SIS and polypropylene mesh implantation into the abdominal wall of rats. Methods: sixty adult Sprague-Dawley rats were randomly divided into 3 groups (20 rats in each group) with 2 cm 脳 2 cm defect in the abdominal wall. The abdominal wall of rats in group A (group A) and group C (group C) were implanted with biofilm in group A (P < 0.05), and compared with group C (group C). Results: there were 4 cases in group A and 3 cases in group B, 3 cases in group C, 3 cases in group C, and 10 cases in group C. there was no difference between the three groups (P 0.05), and there was no difference between the three groups (P 0.05). The proliferation of polypropylene mesh group was obvious, but the foreign body feeling was the strongest, the abdominal wall was stiff, and there were obvious sand particles in SIS mesh group when touching, which were soft and comfortable, but had obvious weak feeling. The suture of the control group was the same as that of the surrounding tissue. Under the electron microscope, the proliferation of the fibrous cells was more active, the number of the fibrous cells was more, the tissue was more compact, the collagen fibers were proliferating and dense. The diameter of collagen fiber was coarse, but the boundary of foreign body was slightly blurred, the larger vessel of multilayer cell wall, the lumen gradually enlarged, the wall thickened gradually and the SIS biological mesh group was sparse, scattered, the number of cells was less, and the effect of collagen fiber proliferation was the worst. In the control group, the fibroblasts proliferate actively, the collagen fibers are dense, the vascular hyperplasia is the least, the wall is the thinnest, the lumen is the smallest, and the surrounding tissues are less. Conclusion: in the polypropylene mesh group, the tissue proliferation is obvious, but the tissue compatibility is good, but the proliferation is not good, but the foreign body sensation is strong, but the proliferation is not good. The connective tissue that provides tension is relatively weak. The development of meshes with respective advantages will be the direction of continuing research and application of pelvic floor biological meshes.
【作者單位】： 復(fù)旦大學(xué)附屬婦產(chǎn)科醫(yī)院上海市生殖內(nèi)分泌相關(guān)疾病重點(diǎn)實(shí)驗(yàn)室;
【基金】：上海市科委基金(No:124119a500) 國(guó)家自然科學(xué)基金面上項(xiàng)目(No:81671439)
【分類號(hào)】：R713

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