發(fā)布時間：2018-03-07 11:49

  本文選題：CD34　切入點：CD44v6　出處：《延邊大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：觀察CD34及CD44v6在子宮腺肌病中的表達(dá),探討其在子宮腺肌病發(fā)生和發(fā)展中的意義。 方法：應(yīng)用免疫組織化學(xué)法檢測40例子宮腺肌病的異位內(nèi)膜、在位內(nèi)膜和10例正常子宮內(nèi)膜中CD34(微血管密度,MVD)及CD44v6的表達(dá)。 結(jié)果：1.MVD在腺肌病異位內(nèi)膜、在位內(nèi)膜及正常子宮內(nèi)膜中分別為43.58±9.28%、30.95±6.66%、9.40±3.06%,各組比較均具有顯著性差異(P0.05)；在位內(nèi)膜中分泌期和增生期內(nèi)膜的MVD分別為32.65±6.41%和28.25±6.63%,差異具有統(tǒng)計學(xué)意義(P0.05)；正常內(nèi)膜中增生期和分泌期內(nèi)膜的MVD無顯著性差異(P0.05)。 2.CD44v6在腺肌病異位內(nèi)膜、在位內(nèi)膜及正常子宮內(nèi)膜中的表達(dá)分別為33.73±8.22%、26.65±7.73%、13.10±6.97%,各組比較均具有顯著性差異(P0.05)；在位內(nèi)膜中分泌期和增生期內(nèi)膜的CD44v6表達(dá)分別為29.45±7.86%、24.85±7.72%,具有顯著性差異(P0.05)；正常內(nèi)膜中增生期和分泌期內(nèi)膜的CD44v6表達(dá)無顯著性差異(P0.05)。 3.CD34與CD44v6在腺肌病的異位內(nèi)膜中的表達(dá)呈正相關(guān)(r=0.6962,P0.05)。 結(jié)論：CD34及CD44v6在子宮腺肌病中表達(dá)上調(diào),在位內(nèi)膜分泌期較增生期表達(dá)增強,提示異位內(nèi)膜促進(jìn)血管生成,利于異位內(nèi)膜生長,且與內(nèi)膜的周期性變化有關(guān)：CD34及CD44v6在子宮腺肌病的發(fā)生發(fā)展和生物學(xué)行為中發(fā)揮協(xié)同作用。
[Abstract]:Aim: to investigate the expression of CD34 and CD44v6 in adenomyosis. Methods: immunohistochemical method was used to detect the expression of CD34 (microvessel density) and CD44v6 in 40 cases of ectopic endometrium, 10 cases of eutopic endometrium and 10 cases of normal endometrium. Results 1. MVD was found in ectopic endometrium of adenomyosis. The MVD of eutopic endometrium and normal endometrium were 43.58 鹵9.28 鹵30.95 鹵6.66 and 9.40 鹵3.06, respectively, and the MVD of secretory and proliferative endometrium in eutopic endometrium were 32.65 鹵6.41% and 28.25 鹵6.63, respectively. There was no significant difference in MVD of secretory endometrium (P 0.05). 2.CD44v6 in ectopic endometrium of adenomyosis, The expressions of CD44v6 in eutopic endometrium and normal endometrium were 33.73 鹵8.22 and 26.65 鹵7.73, respectively. There were significant differences in the expression of CD44v6 between the eutopic endometrium and normal endometrium (P 0.05), and the expression of CD44v6 in secretory and proliferative endometrium of eutopic endometrium was 29.45 鹵7.860.85 鹵7.72respectively, there was significant difference in normal endometrial hyperplasia stage (P0.05). There was no significant difference in the expression of CD44v6 between the secretory endometrium and the secretory endometrium (P 0.05). 3. The expression of CD34 and CD44v6 in the ectopic endometrium of adenomyosis was positively correlated with the expression of rn 0.6962P 0.05. Conclusion the expression of CD34 and CD44v6 was up-regulated in adenomyosis and increased in eutopic endometrium during secretory phase, suggesting that ectopic endometrium could promote angiogenesis and facilitate the growth of ectopic endometrium. In addition, CD 34 and CD44v6 play a synergistic role in the occurrence and development of adenomyosis and the biological behavior of adenomyosis.
【學(xué)位授予單位】：延邊大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R711.71

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本文編號：1579166