本文關(guān)鍵詞： 子宮內(nèi)膜息肉 子宮內(nèi)膜息肉電切術(shù) 左炔諾孕酮宮內(nèi)釋放系統(tǒng) 盆腔炎 胰島素樣生長(zhǎng)因子-　出處：《湖南師范大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2016年06期 　論文類型：期刊論文

【摘要】：目的 :左炔諾孕酮宮內(nèi)釋放系統(tǒng)對(duì)IGF-1的影響及預(yù)防盆腔炎療效分析。方法 :選取2014年1月~2015年11月在我院住院治療的子宮內(nèi)膜息肉患者130例,根據(jù)術(shù)后治療藥物隨機(jī)分為左炔諾孕酮宮內(nèi)釋放系統(tǒng)治療組(觀察組)和去氧孕烯炔雌醇片治療組(對(duì)照組),比較兩組患者治療前后月經(jīng)量和子宮內(nèi)膜厚度、子宮內(nèi)膜IGF-1表達(dá)、以及盆腔炎發(fā)生率的差異。分析盆腔炎發(fā)生與子宮內(nèi)膜IGF-1表達(dá)的關(guān)系,分析子宮內(nèi)膜厚度與子宮內(nèi)膜IGF-1表達(dá)的關(guān)系。結(jié)果 :治療后觀察組患者的月經(jīng)量(33.57±15.62)ml、子宮內(nèi)膜厚度(6.12±0.85)mm均低于對(duì)照組(52.85±15.39)ml和(8.52±0.91)mm,且差異均具有統(tǒng)計(jì)學(xué)差異;治療后觀察組患者的腺皮質(zhì)和間質(zhì)IGF-1表達(dá)(1.41±0.74)和(1.36±0.72)均低于對(duì)照組(1.75±0.82)和(1.72±0.83),且差異均具有統(tǒng)計(jì)學(xué)差異;觀察組盆腔炎的發(fā)生率(6例,9.23%)低于對(duì)照組(17例,26.15%),且差異具有統(tǒng)計(jì)學(xué)差異;治療后發(fā)生盆腔炎的患者腺皮質(zhì)和間質(zhì)IGF-1表達(dá)(1.58±0.81)和(1.62±0.75)均高于未發(fā)生盆腔炎者(1.22±0.71)和(1.32±0.75),且差異均具有統(tǒng)計(jì)學(xué)差異;子宮內(nèi)膜厚度與腺皮質(zhì)IGF-1表達(dá)呈正相關(guān),與間質(zhì)IGF-1表達(dá)呈正相關(guān)。結(jié)論 :左炔諾孕酮宮內(nèi)釋放系統(tǒng)能明顯減少子宮內(nèi)膜息肉患者術(shù)后盆腔炎的發(fā)生率好改善其臨床癥狀,可能因?yàn)樗幬镆种屏俗訉m內(nèi)膜增生和IGF-1表達(dá)從而減少盆腔炎的發(fā)生。
[Abstract]:Objective: to analyze the effect of levonorgestrel intrauterine release system on IGF-1 and the effect of preventing pelvic inflammation. Methods: 130 patients with endometrial polyps who were hospitalized in our hospital from January 2014 to November 2015 were selected. The patients were randomly divided into two groups: levonorgestrel intrauterine release system treatment group (observation group) and deoxypregnenes estradiol treatment group (control group). The menstrual volume, endometrial thickness and endometrial IGF-1 expression were compared between the two groups before and after treatment. And the difference in the incidence of pelvic inflammatory disease. To analyze the relationship between the occurrence of pelvic inflammatory disease and the expression of IGF-1 in endometrium, The relationship between endometrial thickness and endometrial IGF-1 expression was analyzed. Results: after treatment, the menstrual volume and endometrial thickness in the observation group were 33.57 鹵15.62ml and 6.12 鹵0.85mm, respectively, which were lower than those in the control group (52.85 鹵15.39ml and 8.52 鹵0.91mm. respectively). After treatment, the expression of IGF-1 in glandular cortex and stroma in the observation group was 1.41 鹵0.74) and 1.36 鹵0.72 鹵0.72 鹵0.72), which was significantly lower than that in the control group (1.75 鹵0.82) and 1.72 鹵0.83%, and the incidence of pelvic inflammation in the observation group (6 cases) was lower than that in the control group (17 cases), and the difference was statistically significant. The expression of IGF-1 in glandular cortex and stroma of patients with pelvic inflammatory disease after treatment was 1.58 鹵0.81) and 1.62 鹵0.75), which was significantly higher than that in patients without pelvic inflammatory disease (1.22 鹵0.71) and 1.32 鹵0.75.There was a positive correlation between endometrial thickness and IGF-1 expression in glandular cortex. Conclusion: levonorgestrel intrauterine release system can significantly reduce the incidence of pelvic inflammatory disease in patients with endometrial polyps and improve their clinical symptoms. It may be that drugs inhibit endometrial hyperplasia and IGF-1 expression, thereby reducing the incidence of pelvic inflammatory disease.
【作者單位】： 延安大學(xué)附屬醫(yī)院婦科二病區(qū);
【分類號(hào)】：R711.33;R713.4

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