發(fā)布時(shí)間：2018-02-22 07:47

  本文關(guān)鍵詞： 凍融胚胎移植(FET) 短方案 胚胎種植率 妊娠率　出處：《中華生殖與避孕雜志》2017年08期 　論文類(lèi)型：期刊論文

【摘要】：目的分析不同超促排卵方案新鮮胚胎移植和凍融胚胎移植的臨床妊娠結(jié)局,探討全部胚胎冷凍技術(shù)在臨床應(yīng)用中的價(jià)值。方法回顧性分析行胚胎移植的525個(gè)周期患者的臨床資料,其中253個(gè)周期為新鮮胚胎移植周期,272個(gè)周期為同期的復(fù)蘇胚胎移植周期。納入的促排卵方案包括促性腺激素釋放激素激動(dòng)劑(GnRH-a)長(zhǎng)方案組(A組)和GnRH-a短方案組(B組)。分別比較兩組中新鮮胚胎移植和凍融胚胎移植(FET)的妊娠結(jié)局,以及新鮮胚胎移植周期和復(fù)蘇胚胎移植周期中2種方案妊娠結(jié)局。結(jié)果 A組中,新鮮胚胎移植周期(A1組)和FET周期(A2組)的臨床妊娠率分別為45.95%和47.71%(P0.05);B組中,新鮮胚胎移植周期(B1組)和FET(B2組)的臨床妊娠率分別為27.94%和46.30%(P0.05);A1組和B1組的受精率和可用胚胎率組間無(wú)統(tǒng)計(jì)學(xué)差異(P0.05),A組的平均獲卵數(shù)、臨床妊娠率和胚胎種植率顯著高于B組(P0.05);A2組和B2組的臨床妊娠率和胚胎種植率均無(wú)統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論 FET并不能顯著改善長(zhǎng)方案患者的臨床妊娠結(jié)局,但可顯著提高短方案組的臨床妊娠率,提示短方案患者可考慮采用全部胚胎冷凍。
[Abstract]:Objective to analyze the clinical pregnancy outcome of fresh embryo transfer and freeze-thawed embryo transfer in different superovulation schemes. Methods the clinical data of 525 cycles of embryo transfer were analyzed retrospectively. Of these, 253 cycles were fresh embryo transfer cycles and 272 cycles were resuscitation cycles. The ovulation promotion protocols included gonadotropin releasing hormone agonist GnRH-aA group (group A) and GnRH-a short regimen group (group B). The pregnancy outcomes of fresh embryo transfer and frozen thawed embryo transfer were compared between the two groups. Results the clinical pregnancy rates of group A (fresh embryo transfer cycle A1) and FET cycle A 2 (group A) were 45.95% and 47.71% respectively. The clinical pregnancy rates of FET(B2 group and fresh embryo transfer cycle group were 27.94% and 46.30, respectively. There was no significant difference in fertilization rate and available embryo rate between group A and group B1. The clinical pregnancy rate and embryo implantation rate in group B were significantly higher than those in group B (P 0.05) and group B2 (P 0.05). Conclusion FET can not significantly improve the clinical pregnancy outcome of patients with long term regimen. But the clinical pregnancy rate was significantly increased in the short regimen group, suggesting that all embryo cryopreservation could be considered in the short regimen group.
【作者單位】： 棗莊市婦幼保健院生殖中心;
【基金】：山東省自然科學(xué)基金項(xiàng)目(2015ZRA04005)~~
【分類(lèi)號(hào)】：R714.8

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