本文關鍵詞： 胎膜早破 單核細胞趨化蛋白-1 血清降鈣素原 宮頸分泌物　出處：《青島大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:探討孕婦宮頸分泌物中單核細胞趨化蛋白-1及血清降鈣素原與胎膜早破發(fā)生的相關性,分析單核細胞趨化蛋白-1和血清降鈣素原對胎膜早破發(fā)生的預測價值。方法:選擇2015年1月至2016年1月在青島市市立醫(yī)院分娩和門診產檢的孕婦共120例[A組(未足月組),n=60;B組(足月組),n=60]為研究對象根據胎膜早破發(fā)生的孕周:孕28~36+6周和孕≥37周,分為未足月胎膜早破組(A1組,n=30)和足月胎膜早破組(B1組,n=30);相對應篩選同期正常未臨產孕婦為正常對照組,分為未足月健康對照組(A0組,n=30)和足月健康對照組(B0組,n=30)。采用定量雙抗體夾心酶聯免疫吸附(ELISA)法測定宮頸分泌物MCP-1水平,并測定血清降鈣素原含量。各組數據計量資料以(x?s)采用t檢驗進行統(tǒng)計學處理,P≤0.05為具有統(tǒng)計學意義。結果:各組間年齡和未足月胎膜早破與足月胎膜早破間的絨毛膜羊膜炎發(fā)生率并無明顯差異(20%和13.3%,P0.05)。宮頸分泌物MCP-1水平的比較:A1組A0組(70.86±12.76 pg/ml16.64±2.97pg/ml,P0.01),兩組差異具有顯著的統(tǒng)計學意義;B1組B0組(30.26±5.22pg/ml13.19±2.35pg/ml,P0.05),兩組差異具有統(tǒng)計學意義;A1組B1組(70.86±12.76pg/ml30.26±5.22pg/ml,P0.01),兩組差異具有顯著的統(tǒng)計學意義。血清降鈣素原水平的比較:A1組A0組(0.95±0.32ng/ml0.35±0.16ng/ml,P0.05),兩組差異具有統(tǒng)計學意義;B1組B0組(0.25±0.06ng/ml0.05±0.02ng/ml,P0.05),兩組差異具有統(tǒng)計學意義;A1組B1組(0.95±0.32ng/ml0.25±0.06ng/ml,P0.05),兩組差異具有統(tǒng)計學意義。結論:1.胎膜早破孕婦中宮頸分泌物MCP-1水平較正常對照組明顯升高,提示宮頸分泌物MCP-1水平的升高與胎膜早破相關;未足月胎膜早破宮頸分泌物中MCP-1水平明顯高于其他組,推測宮頸分泌物中MCP-1水平升高可能與未足月胎膜早破的關系更密切。2.推測宮頸分泌物MCP-1水平可作為預測未足月胎膜早破發(fā)生的指標。3.未足月胎膜早破孕婦血清降鈣素原明顯升高,推測血清降鈣素原水平在預測未足月胎膜早破中更為敏感。4.宮頸分泌物MCP-1水平和血清降鈣素原水平的聯合檢測或許對未足月胎膜早破的預測具有意義。
[Abstract]:Objective: to investigate the relationship between the occurrence of premature rupture of membranes and monocyte chemoattractant protein-1 and serum procalcitonin in cervical secretion of pregnant women. To analyze the predictive value of monocyte chemoattractant protein-1 and serum procalcitonin on premature rupture of membranes. Methods: 120 pregnant women who gave birth and outpatient delivery in Qingdao City Hospital from January 2015 to January 2016 were selected. According to the gestational weeks of premature rupture of membranes, the gestational weeks were 2836 weeks of gestation and 37 weeks of pregnancy. They were divided into two groups: group A 1 (group A 1) and group B 1 (group B 1). MCP-1 level of cervical secretion and serum procalcitonin content were measured by quantitative double antibody sandwich enzyme linked immunosorbent assay (Elisa) and calcitonin content in serum were measured by quantitative double antibody sandwich enzyme linked immunosorbent assay (Elisa). Results: there was no significant difference in age and the incidence of chorioamnionitis between preterm premature rupture of membranes and premature rupture of full-term membranes in all groups (P < 0.05). There was a significant difference between the two groups (30.26 鹵5.22pg / ml 13.19 鹵2.35pg / ml P 0.05). The difference between the two groups was statistically significant. The difference between the two groups was statistically significant. The difference between the two groups was statistically significant. The serum calcitonin levels in group A1 were 70.86 鹵12.76pg / ml 30.26 鹵5.22pgml / ml respectively. There was a significant difference in serum calcitonin between the two groups. Comparison of the original level: 0.95 鹵0.32ng / ml 0.35 鹵0.16ng / ml P0.05A, there is significant difference between the two groups. Conclusion there is a significant difference between the two groups in the cervical secretion of pregnant women with premature rupture of membranes (0.25 鹵0.06ng / ml 0.05 鹵0.02ng / ml P 0.05), and 0.95 鹵0.32ng / ml 0.25 鹵0.06ng / ml P0.05U in the A1 group. Conclusion there is a significant difference between the two groups in the secretion of cervix in pregnant women with premature rupture of membranes. The level of MCP-1 was significantly higher than that of the normal control group. The results suggest that the increase of MCP-1 level in cervical secretion is related to premature rupture of membranes, and the level of MCP-1 in unmatured premature rupture of cervical membrane is significantly higher than that in other groups. It is speculated that the increase of MCP-1 level in cervical secretion may be more closely related to premature rupture of unmatured membranes. 2. Speculating that the level of MCP-1 in cervical secretion can be used as an index to predict the occurrence of premature rupture of unmatured membranes. 3. The serum level of pregnant women with premature rupture of unfull-term membranes may be decreased. The level of calcitonin was significantly increased. It is speculated that serum procalcitonin level is more sensitive in predicting premature rupture of unmatured membranes. Combined detection of MCP-1 level in cervical secretion and serum procalcitonin level may be of significance for prediction of preterm premature rupture of membranes.
【學位授予單位】：青島大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R714.433

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