本文關鍵詞： 子癇前期 動態(tài)血壓 隨機尿蛋白肌酐比 腎功能　出處：《實用醫(yī)學雜志》2016年21期 　論文類型：期刊論文

【摘要】：目的:探討子癇前期孕婦24 h動態(tài)血壓的特點,晝夜血壓節(jié)律的變化與尿蛋白肌酐比(ACR)、腎功能損害的關系。方法:收集子癇前期孕婦80例進行分析,根據(jù)病情分重度組(A組)35例,輕度組(B組)45例,并選取同期年齡、孕次、體重類似的正常孕婦40例為對照組(C組)。所有研究對象均行24 h動態(tài)血壓監(jiān)測(ABPM),分析24 h血壓的特點及晝夜節(jié)律性。隨機留取中段尿行ACR檢測,比較3組ACR及腎功能指標水平。對子癇前期孕婦ABPM指標與隨機ACR、腎功能指標行相關性分析。結果:(1)A組24 h SBP、24 h DBP、d SBP、n SBP、n DBP、d MAP、n MAP、SL、d HR、n HR、24 h HR明顯高于B組(P0.05)。A及B組MBP10%,晝夜血壓呈"非杓型"改變A組占88%,B組占67%。(2)A組血BNU、SCR、SUA及ACR均明顯高于B、C組,B組ACR明顯高于C組(P0.05)。(3)相關分析示d MAP、n MAP與SCR、SUA、ACR分別呈正相關,MBP與SCR、SUA、ACR分別呈負相關;ACR與BUN、SCR、SUA分別呈正相關(P0.05)。結論:子癇前期孕婦晝夜血壓節(jié)律性多數(shù)呈"非杓型",血壓升高水平及晝夜節(jié)律性改變與ACR、腎功能指標升高密切相關,ACR能反映尿蛋白的排泄及腎臟受損的程度。
[Abstract]:Objective: to investigate the characteristics of 24 h ambulatory blood pressure (ABBP) in preeclampsia pregnant women, and the relationship between the circadian blood pressure rhythm and urinary creatinine ratio (CRR) and renal dysfunction. Methods: 80 pregnant women with preeclampsia were collected and analyzed. According to the disease condition, 35 cases were divided into two groups: group A (35 cases) and group B (45 cases). 40 normal pregnant women with similar body weight were selected as control group C. All subjects were given 24 h ambulatory blood pressure monitoring (ABPM), and the characteristics and circadian rhythm of 24 h blood pressure were analyzed. ACR was detected by random sampling of urine in middle part of the study. The correlation between ABPM and random ABPM and renal function index in preeclampsia pregnant women were compared. Results the HR of 24 h SBPnSBPnDBPnMAPNMAPN MAPD MAPD MAPN HRN HR24 h in group A was significantly higher than that in group B (P 0.05N) and group B (MBP10), while in group B (group B), it was higher than that in group B (P 0.05) and in group B (group B), and in the daytime, it was found that in group B, it was higher than that in group B (P 0.05A) and in group B (group B). Nocturnal blood pressure was "non-dipper" in group A and group A had significantly higher serum BNU-SCRS-SUA and ACR than those in group B and group B, respectively. The correlation analysis showed that d MAPN MAP was significantly higher than that of group C (P0.05. 3) correlation analysis showed that there was a positive correlation between d MAPN MAP and SCRSUAACR. MBP was negatively correlated with ACR and BUNSCRSUAA was negatively correlated with BUNSCRSUA respectively (P < 0. 05, P < 0. 05, P < 0. 05); the correlation analysis showed that there was a positive correlation between d MAPN MAP and SCR SUAACR in group A (P < 0. 05). Conclusion: the circadian blood pressure rhythm of preeclampsia pregnant women is "non-dipper", and the elevation of blood pressure and the circadian rhythm are closely related to ACR.ACR can reflect the excretion of urine protein and the degree of renal damage.
【作者單位】： 廣東省惠州市第一婦幼保健院內(nèi)科;
【分類號】：R714.244

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