發(fā)布時(shí)間：2018-01-31 22:50

  本文關(guān)鍵詞： 宮腔內(nèi)人工授精(IUI) 自然周期(NC) 促排卵周期(OIC) 臨床妊娠率 活產(chǎn)率　出處：《生殖與避孕》2016年10期 　論文類(lèi)型：期刊論文

【摘要】：目的:探討促排卵對(duì)不同病因不孕患者人工授精的影響。方法:回顧性分析因男性因素、輸卵管盆腔因素、子宮內(nèi)膜異位癥(EMS)和不明原因進(jìn)行人工授精患者的資料,根據(jù)患者進(jìn)行自然周期或促排卵周期分組,比較不同周期組的臨床妊娠率和活產(chǎn)率。采用多元回歸分析模型校正患者年齡、不孕年限、不同因素構(gòu)成比、基礎(chǔ)FSH、LH、E_2、子宮內(nèi)膜厚度、類(lèi)型、宮腔內(nèi)人工授精(IUI)日卵泡直徑及男性前向運(yùn)動(dòng)精子總數(shù)。評(píng)估在男性因素、輸卵管盆腔因素、EMS和不明原因中促排卵周期與臨床妊娠率的關(guān)系。結(jié)果:①促排卵組患者平均年齡、不孕年限以及不孕因素構(gòu)成比(男性因素、輸卵管盆腔因素、EMS和不明原因)與自然周期比較,無(wú)統(tǒng)計(jì)學(xué)差異(P0.05),而臨床妊娠率和活產(chǎn)率均高于自然周期,但無(wú)統(tǒng)計(jì)學(xué)差異(P=0.08);②通過(guò)多元因素回歸分析校正了年齡、基礎(chǔ)內(nèi)分泌水平、不孕因素、內(nèi)膜厚度和類(lèi)型及前向運(yùn)動(dòng)精子總數(shù)等混雜因素后,促排卵周期相對(duì)于自然周期依然有顯著優(yōu)勢(shì)(OR=1.607;95%CI=1.115~2.316);③在不同因素不孕患者中,促排卵周期可提高輸卵管盆腔因素患者的活產(chǎn)率(OR=4.56;95%CI=1.53~13.53)。結(jié)論:促排卵周期可提高輸卵管盆腔因素患者宮腔內(nèi)人工授精的臨床妊娠和活產(chǎn)率。
[Abstract]:Objective: to investigate the effect of ovulation promotion on artificial insemination in infertile patients with different etiology. The data of patients with endometriosis (EMSs) and patients with artificial insemination for unknown reasons were divided into groups according to the patients' natural cycle or ovulation promoting cycle. The clinical pregnancy rate and live delivery rate were compared in different cycle groups. Multivariate regression model was used to calibrate the patients' age, infertility years, ratio of different factors composition, basic FSHLHHHG E2, endometrial thickness. Type intrauterine intrauterine insemination IUI day follicle diameter and total number of male forward motility spermatozoa evaluated in male factors and tubal pelvic factors. Results the mean age, infertile years and the ratio of infertile factors (male factors, pelvic factors) in the ovulation promoting group were significantly higher than those in the control group (male, oviduct and pelvic factors), the relationship between ovulation induction cycle and clinical pregnancy rate was found in EMS and unexplained reasons. There was no statistical difference between EMS and the natural cycle, but the clinical pregnancy rate and the live birth rate were higher than those of the natural cycle, but there was no statistical difference between the clinical pregnancy rate and the live birth rate, but there was no statistical difference between the clinical pregnancy rate and the live birth rate. 2After multivariate regression analysis, the mixed factors such as age, basal endocrine level, infertility, intimal thickness and type, and total number of forward motile sperm were corrected. The ovulation promoting cycle still has a significant advantage over the natural cycle. (95) CII 1.115 / 2.316m; (3) in infertile patients with different factors, ovulation induction cycle could increase the live birth rate of patients with tubal and pelvic factors. Conclusion: ovulation promotion cycle can improve the clinical pregnancy and live birth rate of patients with pelvic and fallopian tube factors.
【作者單位】： 解放軍第一七四醫(yī)院生殖醫(yī)學(xué)中心;
【分類(lèi)號(hào)】：R711.6
【正文快照】： 宮腔內(nèi)人工授精(intrauterine insemination,IUI)是指在排卵期將處理后的男方精液注入女性宮腔內(nèi),是一項(xiàng)常用的治療不孕癥的技術(shù),方法簡(jiǎn)單,創(chuàng)傷性小,臨床應(yīng)用廣泛。1984年Sher等首次應(yīng)用控制性促排卵后IUI治療各種原因引起的難治性不孕癥[1],經(jīng)一個(gè)周期的治療,妊娠率達(dá)35%。自

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