本文關(guān)鍵詞： 子宮肌瘤 超聲消融 超聲對(duì)比劑　出處：《介入放射學(xué)雜志》2016年10期 　論文類(lèi)型：期刊論文

【摘要】：目的 探討六氟化硫微泡在高強(qiáng)度聚焦超聲(HIFU)治療子宮肌瘤中的臨床應(yīng)用價(jià)值。方法 2011年8月至2013年8月入院診斷為子宮肌瘤患者隨機(jī)分成造影組(n=30)與非造影組(n=30),造影組HIFU治療術(shù)前、中、后用六氟化硫微泡造影,非造影組術(shù)后造影。記錄手術(shù)時(shí)間、出現(xiàn)塊狀灰度變化時(shí)間、輻照時(shí)間、腫瘤消融率、治療劑量(J),兩組參數(shù)用兩獨(dú)立樣本t檢驗(yàn)。結(jié)果 造影組手術(shù)時(shí)間、出現(xiàn)塊狀灰度變化時(shí)間、輻照時(shí)間、治療劑量分別為(71.71±53.22)min,(528.74±379.14)s,(827.97±696.43)s,(295 581.81±207 182.29)J,非造影組分別為(148.14±65.12)min,(1 171.42±877.42)s,(1 770.43±1 357.62)s,(597 705.71±464 389.85)J,兩組各參數(shù)相比差異有統(tǒng)計(jì)學(xué)意義(P0.05)。肌瘤消融率造影組為(78.42±5.77)%,非造影組為(76.10±10.11)%,兩組各參數(shù)相比差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。造影組患者未發(fā)生治療區(qū)皮膚燒傷、下肢麻木,1例出現(xiàn)全身酸麻,并發(fā)癥的發(fā)生率為1/30(3.3%)。非造影組治療區(qū)皮膚Ⅱ度燒傷1例,下肢麻木1例,全身酸麻2例,并發(fā)癥的發(fā)生率為4/30(13.3%),高于前者(P0.001),差異有統(tǒng)計(jì)學(xué)意義。結(jié)論 六氟化硫微泡在HIFU熱消融子宮肌瘤中,可縮短手術(shù)時(shí)間,提高腫瘤消融率,減少并發(fā)癥,具有明顯的增效作用,在臨床中發(fā)揮著重要的指導(dǎo)意義。
[Abstract]:Objective to investigate the application of sulfur hexafluoride microbubbles in high intensity focused ultrasound (HIFU). Methods from August 2011 to August 2013, the patients diagnosed as uterine leiomyoma were randomly divided into two groups: the contrast group (n = 30) and the non-contrast group (n = 30). Before, during and after HIFU treatment in the contrast group, the HIFU group was treated with sulfur hexafluoride microbubble angiography, while in the non-contrast group, the operation time, the time of massive gray level change, the irradiation time and the ablation rate of tumor were recorded. The parameters of the two groups were tested with two independent samples t. Results in the contrast group, the operation time, the time of massive gray scale change and the irradiation time were observed. The therapeutic doses were 71.71 鹵53.22 min, 528.74 鹵379.14 min, 827.97 鹵696.43 Ms, respectively. In the non-contrast group, it was 148.14 鹵65.12 min ~ (-1) 171.42 鹵877.42 Ms, respectively. 597 705.71 鹵464 389.85J. The ablation rate of myoma was 78.42 鹵5.77% in contrast group and 76.10 鹵10.11% in non-contrast group. There was no significant difference in the parameters between the two groups (P 0.05). In the contrast group, there was no skin burn in the treatment area, and 1 patient with numbness of lower extremity developed general acid anesthesia. The incidence of complications was 1 / 30 ~ 3.3%. In the non-contrast group, there were 1 case of second degree skin burn, 1 case of numbness of lower extremity, 2 cases of general acid anesthesia, and the incidence of complications was 430% 13.3%. Conclusion sulfur hexafluoride microbubbles in HIFU thermal ablation of uterine leiomyoma can shorten the operation time, improve the ablation rate and reduce complications. It has obvious synergistic effect and plays an important guiding role in clinical practice.
【作者單位】： 昆明醫(yī)科大學(xué)第一附屬醫(yī)院醫(yī)學(xué)影像科;
【分類(lèi)號(hào)】：R737.33
【正文快照】： 高強(qiáng)度聚焦超聲(high-intensityfocusedultrasound,HIFU)治療子宮肌瘤安全、有效、微創(chuàng)。如何縮短手術(shù)時(shí)間,提高腫瘤消融率,現(xiàn)已成為臨床研究的重點(diǎn)。六氟化硫微泡系第2代超聲對(duì)比劑,術(shù)前應(yīng)用可明確肌瘤位置、邊界、血供與周?chē)M織的關(guān)系,術(shù)中可實(shí)時(shí)掌握腫瘤消融范圍。研究發(fā)

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本文編號(hào)：1468185