本文關(guān)鍵詞： 輔助生殖技術(shù) 卵巢儲(chǔ)備功能下降 子代 健康　出處：《浙江大學(xué)》2015年博士論文　論文類型：學(xué)位論文

【摘要】：卵巢儲(chǔ)備功能(ovarian reserve)指卵巢產(chǎn)生卵子數(shù)量和質(zhì)量的潛能,其間接反映了卵巢的功能。卵巢儲(chǔ)備功能下降(diminished ovarian reserve, DOR)是指有規(guī)律月經(jīng)的育齡女性由于各種已知或不明原因引發(fā)的卵巢功能障礙,而導(dǎo)致卵巢對(duì)刺激的反應(yīng)性或生育力較同齡女性下降。卵巢儲(chǔ)備功能下降可能涉及了卵子數(shù)量、卵子質(zhì)量和生育潛能三方面的改變。已有研究發(fā)現(xiàn)卵巢儲(chǔ)備功能下降可能與ART治療時(shí)的卵巢低反應(yīng)、高移植取消率和妊娠失敗相關(guān)。目前關(guān)于卵巢儲(chǔ)備功能下降對(duì)卵子質(zhì)量的影響的研究都是關(guān)于卵子的受精能力和受精卵的著床能力改變的研究。迄今尚未有DOR患者的卵子質(zhì)量是否在影響子代健康的方面有改變的報(bào)道。為了彌補(bǔ)這一空白,本研究將符合納入標(biāo)準(zhǔn)的接受輔助生殖技術(shù)治療并且成功受孕分娩子代的不孕患者按照基礎(chǔ)FSH值進(jìn)行分組,基礎(chǔ)FSH值大于10IU/L并小于40IU/L的不孕患者分入DOR組,基礎(chǔ)FSH值小于或等于10IU/L的不孕患者分入對(duì)照NOR (normal ovarian reserve)組。統(tǒng)計(jì)分析顯示DOR組患者的獲卵數(shù)明顯少于NOR組。而兩組子代的智商和新生兒黃疸、先天畸形、高血壓、高血脂、空腹血糖異常、肝功能異常、甲狀腺功能異常的發(fā)生率,均沒(méi)有發(fā)現(xiàn)明顯統(tǒng)計(jì)學(xué)差異。結(jié)論：綜上證明DOR不孕患者的卵子質(zhì)量在影響子代健康方面沒(méi)有改變。
[Abstract]:The ovarian reserve function (ovarian reserve) refers to the number and quality of eggs to produce ovarian potential, the indirectly reflects the function of ovary. The diminished ovarian reserve (diminished ovarian reserve, DOR) refers to the ovarian dysfunction with regular menstrual women of childbearing age due to a variety of known or unknown causes, which lead to ovarian response to stimuli or female fertility was decreased. The diminished ovarian reserve may involve a number of eggs, egg quality and fertility potential of three aspects of change. It has been found that the diminished ovarian reserve and ovarian response to ART treatment, high graft rate and pregnancy failure. To cancel the current research on the decline of ovarian reserve function influence on egg quality the research is about changing the fertilization ability and the implantation of the fertilized egg ability. So far there is no DOR with egg quality In the health of the offspring are reported. In order to change to fill this gap, this study will meet the inclusion criteria of receiving assisted reproductive technology treatment and pregnancy childbirth offspring of infertile patients with FSH were grouped in accordance with the basic value, the FSH value is greater than 10IU/L and less than 40IU/ L infertility patients were divided into DOR group, foundation the FSH value is less than or equal to 10IU/L infertility were divided into control group NOR (normal ovarian reserve). Statistical analysis showed that the number of oocytes in DOR group were significantly less than NOR group. The IQ and neonatal jaundice, two offspring of congenital malformation, high blood pressure, high blood lipid, fasting blood glucose abnormalities, abnormal liver function. The prevalence of thyroid dysfunction, were found no statistically significant difference. Conclusions: the proof of DOR infertility patients in egg quality effects on offspring health did not change.

【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2015
【分類號(hào)】：R714.8

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本文編號(hào)：1468105