本文關(guān)鍵詞： 原因不明復(fù)發(fā)性流產(chǎn) 濾泡性輔助T細胞 CXCR CCR 蛻膜 流式細胞術(shù)　出處：《上海交通大學(xué)學(xué)報(醫(yī)學(xué)版)》2017年10期 　論文類型：期刊論文

【摘要】：目的·探討原因不明復(fù)發(fā)性流產(chǎn)(URSA)的發(fā)生與濾泡性輔助T細胞(Tfh)亞型的關(guān)系。方法·以28例正常人工流產(chǎn)患者為對照組,28例染色體正常的URSA患者為流產(chǎn)組。分離2組患者外周血及子宮蛻膜組織中單個核細胞,用流式細胞術(shù)檢測CXCR3~+CCR6~-、CXCR3~-CCR6~-及CXCR3~-CCR6~+3種Tfh細胞亞型水平及B細胞水平。結(jié)果·流產(chǎn)組蛻膜組織CXCR3~-CCR6~-Tfh細胞水平顯著高于對照組(P=0.015),且與B細胞水平有相關(guān)性(R~2=0.779,P=0.025)。2組蛻膜組織中另外2種Tfh細胞亞型水平以及外周血中3種Tfh細胞亞型水平差異均無統(tǒng)計學(xué)意義(均P0.05)。結(jié)論·早孕婦女蛻膜組織局部CXCR3-CCR6-Tfh細胞亞型數(shù)量增多可能與URSA發(fā)生有關(guān)。
[Abstract]:Objective: to investigate the relationship between the occurrence of recurrent abortion with unknown cause and the subtype of follicular assistant T cell (TfH). Methods: 28 normal abortion patients were taken as control group. The mononuclear cells in peripheral blood and decidua tissues were isolated from 28 URSA patients with normal chromosomes, and CXCR3- CCR6- were detected by flow cytometry. CXCR3ON-CCR6ON- and CXCR3ON-CCR6 ~. Results the levels of CXCR3~-CCR6~-Tfh cells in decidual tissue in abortion group were significantly higher than those in control group (P < 0.05). P0. 015). And there was a correlation with B cell level. There was no significant difference in the levels of the other two Tfh cell subtypes in decidual tissues and the three Tfh cell subtypes in peripheral blood (all P 0.05). Conclusion: the increased number of local CXCR3-CCR6-Tfh cell subtypes in decidual tissue of early pregnant women may be related to the occurrence of URSA.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬仁濟醫(yī)院婦產(chǎn)科;
【分類號】：R714.21
【正文快照】： 連續(xù)發(fā)生3次或3次以上的自然流產(chǎn)者稱為復(fù)發(fā)性URSA的發(fā)生存在關(guān)聯(lián)。流產(chǎn)(recurrent spontaneous abortion,RSA)[1],其中有60%~80%的患者因致病原因不詳,稱為原因不明復(fù)發(fā)性1對象與方法流產(chǎn)(unexplained recurrent spontaneous abortion,URSA)[2]。近年來,URSA發(fā)病率逐漸上升,

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