發(fā)布時間：2018-01-26 23:25

  本文關鍵詞： 卵巢腫瘤 成熟性畸胎瘤 惡變 臨床病理　出處：《臨床與實驗病理學雜志》2015年01期 　論文類型：期刊論文

【摘要】：目的探討22例卵巢成熟性畸胎瘤惡變的臨床病理學特征。方法回顧性分析1 826例卵巢成熟性畸胎瘤,對其中22例伴有體細胞惡變的病例進行臨床病理學特征分析并行免疫組化染色。結果 22例成熟性畸胎瘤惡變占同期1 826例卵巢畸胎瘤的1.2%�；颊吣挲g31~79歲,平均56.5歲。臨床主要表現(xiàn)為盆腔包塊,其中惡變位于左側卵巢13例,右側8例,雙側同時累及1例。畸胎瘤大體呈囊性19例,囊實性3例,其中雙側發(fā)生的1例左側為實性、右側為囊性�；チ鲎畲髲�5.0~30.0 cm,平均12.4 cm;惡變成分最大徑1.0~10.0 cm,平均3.7 cm。惡變成分為中~低分化鱗狀細胞癌14例、類癌4例、腺癌2例、甲狀腺乳頭狀癌2例、肉瘤樣癌1例。臨床分期:ⅠA期16例,ⅠB期1例,ⅡA期1例,ⅡB期4例。隨訪6例復發(fā),2例死亡,其余截止隨訪時均存活。結論卵巢成熟性畸胎瘤中伴有體細胞惡變的發(fā)生率低,多見于絕經后女性并表現(xiàn)為盆腔包塊,惡變成分組織學上以鱗狀細胞癌多見,Ⅰ期患者預后較好。臨床與病理醫(yī)師應重視成熟性畸胎瘤的全面檢查及診斷,以防漏診其中的惡變成分。
[Abstract]:Objective to investigate the clinicopathological features of 22 cases of ovarian mature teratoma. Methods 1826 cases of ovarian mature teratoma were retrospectively analyzed. The clinicopathological characteristics of 22 cases with somatic malignancy were analyzed and immunohistochemical staining was performed. Results 22 cases of malignant transformation of mature teratoma accounted for 1. The age of 826 patients with ovarian teratoma was 31 to 79 years old. The mean age was 56.5 years. The main clinical manifestations were pelvic mass, including 13 cases of malignant transformation in left ovary, 8 cases of right side, and 1 case of bilateral involvement simultaneously. There were 19 cases of teratoma and 3 cases of cystic solid. One case had solid on the left side and the other was cystic on the right. The maximum diameter of teratoma was 5.0 ~ 30.0 cm (mean 12.4 cm). The maximum diameter of malignant components was 1.0 ~ 10.0 cm, with an average of 3.7 cm. The malignant components were moderately to poorly differentiated squamous cell carcinoma (14 cases), carcinoid (4 cases), adenocarcinoma (2 cases) and thyroid papillary carcinoma (2 cases). There were 1 case of sarcomatoid carcinoma, 16 cases of stage 鈪，

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