本文關(guān)鍵詞： 不孕癥 克羅米芬 戊酸雌二醇 芬嗎通雌二醇 子宮內(nèi)膜容受性　出處：《山東醫(yī)藥》2015年28期 　論文類型：期刊論文

【摘要】：目的觀察克羅米芬(CC)促排卵后分別接受戊酸雌二醇(補佳樂)、芬嗎通雌二醇治療的不孕癥患者子宮內(nèi)膜容受性。方法選擇CC促排卵后子宮內(nèi)膜變薄的不孕癥患者120例,隨機分為三組,均于月經(jīng)第8天開始補充外源性雌激素,A組補佳樂口服及陰道用藥,B組口服補佳樂,C組芬嗎通雌二醇片口服及陰道用藥;分別于用藥3 d后及人絨毛膜促性腺激素(HCG)日下午行陰道超聲檢查,比較三組子宮內(nèi)膜厚度、類型、容積及內(nèi)膜下血流情況,并隨訪臨床妊娠率。結(jié)果補充雌激素3 d后,A、B、C組子宮內(nèi)膜厚度分別為(6.57±1.21)、(7.00±1.11)、(7.74±1.37)mm,HCG日分別為(8.08±2.12)、(8.70±2.17)、(9.96±2.38)mm,C組B組A組(P均0.05)。補充雌激素3 d后,A、B、C組子宮內(nèi)膜容積≥2 m L分別為15、18、25例,HCG日分別為20、22、31例,C組均多于A、B組(P均0.05);三組子宮內(nèi)膜類型、內(nèi)膜下血流比較均無統(tǒng)計學(xué)差異(P均0.05)。A、B、C組臨床妊娠率分別為17.5%、20.0%、25.0%,組間比較,P均0.05。結(jié)論與補佳樂比較,芬嗎通雌二醇片可明顯改善CC促排卵后子宮內(nèi)膜變薄的不孕癥患者內(nèi)膜厚度及容積,但在子宮內(nèi)膜類型、子宮內(nèi)膜下血流及臨床妊娠率方面比較無統(tǒng)計學(xué)差異。
[Abstract]:Objective to observe the effect of estradiol valerate on ovulation induced by clomiphene. Methods 120 infertile patients with infertility treated with fentone estradiol were randomly divided into three groups. On the 8th day of menstruation, oral administration of Bujialao in group A of exogenous estrogen and oral administration of Fenmatone estradiol in group B and oral administration of fentone estradiol in group B were performed. The thickness, type, volume and subendometrial blood flow of the three groups were examined by vaginal ultrasound 3 days after treatment and on the afternoon of human chorionic gonadotropin (HCG). Results the endometrial thickness was 6.57 鹵1.21 in group C after estrogen supplementation for 3 days, and 7.00 鹵1.11 in group A (P < 0.05). The HCG days of 7.74 鹵1.37 mm / d were 8.08 鹵2.12 鹵8.70 鹵2.17 鹵9.96 鹵2.38 mm respectively. The endometrial volume 鈮，

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